PMID- 12754510
OWN - NLM
STAT- MEDLINE
DCOM- 20030703
LR  - 20061115
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 34
IP  - 2
DP  - 2003 Jun
TI  - Positional cloning of a quantitative trait locus on chromosome 13q14 that 
      influences immunoglobulin E levels and asthma.
PG  - 181-6
AB  - Atopic or immunoglobulin E (IgE)-mediated diseases include the common disorders 
      of asthma, atopic dermatitis and allergic rhinitis. Chromosome 13q14 shows 
      consistent linkage to atopy and the total serum IgE concentration. We previously 
      identified association between total serum IgE levels and a novel 13q14 
      microsatellite (USAT24G1; ref. 7) and have now localized the underlying 
      quantitative-trait locus (QTL) in a comprehensive single-nucleotide polymorphism 
      (SNP) map. We found replicated association to IgE levels that was attributed to 
      several alleles in a single gene, PHF11. We also found association with these 
      variants to severe clinical asthma. The gene product (PHF11) contains two PHD 
      zinc fingers and probably regulates transcription. Distinctive splice variants 
      were expressed in immune tissues and cells.
FAU - Zhang, Youming
AU  - Zhang Y
AD  - Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, 
      Oxford OX3 7BN, UK.
FAU - Leaves, Nicholas I
AU  - Leaves NI
FAU - Anderson, Gavin G
AU  - Anderson GG
FAU - Ponting, Chris P
AU  - Ponting CP
FAU - Broxholme, John
AU  - Broxholme J
FAU - Holt, Richard
AU  - Holt R
FAU - Edser, Pauline
AU  - Edser P
FAU - Bhattacharyya, Sumit
AU  - Bhattacharyya S
FAU - Dunham, Andy
AU  - Dunham A
FAU - Adcock, Ian M
AU  - Adcock IM
FAU - Pulleyn, Louise
AU  - Pulleyn L
FAU - Barnes, Peter J
AU  - Barnes PJ
FAU - Harper, John I
AU  - Harper JI
FAU - Abecasis, Goncalo
AU  - Abecasis G
FAU - Cardon, Lon
AU  - Cardon L
FAU - White, Melanie
AU  - White M
FAU - Burton, John
AU  - Burton J
FAU - Matthews, Lucy
AU  - Matthews L
FAU - Mott, Richard
AU  - Mott R
FAU - Ross, Mark
AU  - Ross M
FAU - Cox, Roger
AU  - Cox R
FAU - Moffatt, Miriam F
AU  - Moffatt MF
FAU - Cookson, William O C M
AU  - Cookson WO
LA  - eng
SI  - GENBANK/AF155105
SI  - GENBANK/AL552215
SI  - GENBANK/BE787177
SI  - GENBANK/BF662927
SI  - GENBANK/BG759124
SI  - GENBANK/BI463029
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Alternative Splicing
MH  - Asthma/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Female
MH  - Haplotypes
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Molecular Sequence Data
MH  - Polymorphism, Single Nucleotide
MH  - *Quantitative Trait Loci
MH  - Tissue Distribution
MH  - Zinc Fingers/genetics
EDAT- 2003/05/20 05:00
MHDA- 2003/07/04 05:00
CRDT- 2003/05/20 05:00
PHST- 2002/12/21 00:00 [received]
PHST- 2003/04/18 00:00 [accepted]
PHST- 2003/05/20 05:00 [pubmed]
PHST- 2003/07/04 05:00 [medline]
PHST- 2003/05/20 05:00 [entrez]
AID - ng1166 [pii]
AID - 10.1038/ng1166 [doi]
PST - ppublish
SO  - Nat Genet. 2003 Jun;34(2):181-6. doi: 10.1038/ng1166.