PMID- 12755490
OWN - NLM
STAT- MEDLINE
DCOM- 20031104
LR  - 20210108
IS  - 0167-6806 (Print)
IS  - 0167-6806 (Linking)
VI  - 78
IP  - 3
DP  - 2003 Apr
TI  - The 17q23 amplicon and breast cancer.
PG  - 313-22
AB  - A novel region of amplification in breast tumors was recently identified on 
      chromosome 17q23. Extensive mapping of the amplicon by Southern blotting and 
      fluorescence in situ hybridization (FISH) in breast cancer cell lines determined 
      that the amplicon can be up to 4 Mbp in size and may contain 50 genes. Copy 
      number analysis at 50-75 kb resolution in breast cancer cell lines and breast 
      tumors identified several independently amplified regions within the amplicon, 
      suggesting that a number of genes are selected for amplification because they 
      independently contribute to tumor formation and progression. Support for this 
      hypothesis comes from studies demonstrating that many of the amplified genes are 
      over-expressed in breast cancer cell lines and tumors, and that the RPS6KB1, 
      TBX2, and PPM1D genes from the region, that are amplified and over-expressed in 
      breast tumors and cell lines, contribute to tumor formation and/or tumor 
      progression. In this review we summarize the structural studies of the amplicon 
      that have been carried out, we outline the evidence implicating the RPS6KB1, 
      TBX2, and PPM1D genes as oncogenes, and we describe some of the other candidate 
      oncogenes from the region.
FAU - Sinclair, Colleen S
AU  - Sinclair CS
AD  - Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.
FAU - Rowley, Matthew
AU  - Rowley M
FAU - Naderi, Ali
AU  - Naderi A
FAU - Couch, Fergus J
AU  - Couch FJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Breast Cancer Res Treat
JT  - Breast cancer research and treatment
JID - 8111104
SB  - IM
MH  - Breast Neoplasms/*genetics
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 17
MH  - Female
MH  - Gene Amplification
MH  - Gene Dosage
MH  - Gene Expression Profiling
MH  - Humans
MH  - Oncogenes
RF  - 63
EDAT- 2003/05/21 05:00
MHDA- 2003/11/05 05:00
CRDT- 2003/05/21 05:00
PHST- 2003/05/21 05:00 [pubmed]
PHST- 2003/11/05 05:00 [medline]
PHST- 2003/05/21 05:00 [entrez]
AID - 10.1023/a:1023081624133 [doi]
PST - ppublish
SO  - Breast Cancer Res Treat. 2003 Apr;78(3):313-22. doi: 10.1023/a:1023081624133.