PMID- 12759116
OWN - NLM
STAT- MEDLINE
DCOM- 20040107
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 75
IP  - 1
DP  - 2003 Apr
TI  - Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following 
      exercise and antidepressant.
PG  - 81-8
AB  - Antidepressants and physical exercise have been shown to increase the 
      transcription of hippocampal brain-derived neurotrophic factor (BDNF). Much 
      evidence regarding the initial actions of antidepressant medications as well as 
      exercise leads to the hypothesis that noradrenergic (NE) and/or serotonergic 
      (5-HT) activation is a key element in the BDNF transcriptional elevation common 
      to both interventions. Currently, we used short-term beta-adrenergic, 5-HT(1A), 
      or 5-HT(2A/C) receptor blockade to characterize the influence of NE and 5-HT 
      systems on BDNF transcription during physical exercise and antidepressant 
      treatment. In situ hybridization revealed that beta-adrenergic blockade 
      significantly blunted the BDNF mRNA elevations due to exercise, and also 
      inhibited the modest elevations in the CA3 and dentate gyrus following short-term 
      treatment with tranylcypromine. In contrast, 5-HT(2A/C) blockade only minimally 
      altered exercise-induced BDNF mRNA levels, but inhibited up-regulation of BDNF 
      transcription via tranylcypromine. Finally, 5-HT(1A) blockade did not inhibit 
      exercise-induced BDNF mRNA elevations, but significantly enhanced levels above 
      those achieved with exercise alone in the CA4. These results suggest that NE 
      activation via beta-adrenergic receptors may be essential for both exercise and 
      antidepressant-induced BDNF regulation. 5-HT(1A) and 5-HT(2A/C) activation, on 
      the other hand, appear to be most important for antidepressant-induced BDNF 
      regulation, but may also participate significantly in exercise-induced regulation 
      in the CA4.
FAU - Ivy, A S
AU  - Ivy AS
AD  - Department of Biological Sciences, California State University Los Angeles, 5151 
      State University Drive, Los Angeles, CA 90032, USA.
FAU - Rodriguez, F G
AU  - Rodriguez FG
FAU - Garcia, C
AU  - Garcia C
FAU - Chen, M J
AU  - Chen MJ
FAU - Russo-Neustadt, A A
AU  - Russo-Neustadt AA
LA  - eng
GR  - MH 59776/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Adrenergic Antagonists)
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Piperazines)
RN  - 0 (Pyridines)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serotonin Antagonists)
RN  - 3E3V44J4Z9 (Tranylcypromine)
RN  - 71IH826FEG 
      (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide)
RN  - 97F9DE4CT4 (Ketanserin)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenergic Antagonists/*pharmacology
MH  - Adrenergic beta-Antagonists/pharmacology
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Biotransformation/drug effects
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Hippocampus/drug effects/metabolism
MH  - In Situ Hybridization
MH  - Ketanserin/pharmacology
MH  - Male
MH  - Norepinephrine/*antagonists & inhibitors
MH  - Physical Exertion/*physiology
MH  - Piperazines/pharmacology
MH  - Propranolol/pharmacology
MH  - Pyridines/pharmacology
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Running/physiology/psychology
MH  - Serotonin Antagonists/*pharmacology
MH  - Tranylcypromine/pharmacology
MH  - Up-Regulation/drug effects
EDAT- 2003/05/22 05:00
MHDA- 2004/01/08 05:00
CRDT- 2003/05/22 05:00
PHST- 2003/05/22 05:00 [pubmed]
PHST- 2004/01/08 05:00 [medline]
PHST- 2003/05/22 05:00 [entrez]
AID - S0091305703000443 [pii]
AID - 10.1016/s0091-3057(03)00044-3 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2003 Apr;75(1):81-8. doi: 10.1016/s0091-3057(03)00044-3.