PMID- 12759518
OWN - NLM
STAT- MEDLINE
DCOM- 20040220
LR  - 20201208
IS  - 1424-8832 (Print)
IS  - 1424-8832 (Linking)
VI  - 32
IP  - 4
DP  - 2002 Jul-Aug
TI  - Effect of phenprocoumon on monitoring of lepirudin, argatroban, melagatran and 
      unfractionated heparin with the PiCT method.
PG  - 174-9
AB  - Prothrombinase-induced clotting time (PiCT) is a clotting-time test for heparins 
      and direct thrombin inhibitors to reduce drawbacks of aPTT. Effects of the direct 
      thrombin inhibitors lepirudin, argatroban, melagatran and of unfractionated 
      heparin (UFH) were investigated in normal and oral anticoagulant plasma samples. 
      Lepirudin showed potentiating interferences with phenprocoumon effects. 
      Melagatran, argatroban and UFH delivered distinct linear additive effects in both 
      plasma sample groups. PiCT ratio reduces differences between both groups with 
      UFH, and argatroban inhibitor-receptor-binding mode plays a role in interaction 
      patterns.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Fenyvesi, T
AU  - Fenyvesi T
AD  - Fourth Medical Department, University Hospital, Mannheim, Germany.
FAU - Jorg, I
AU  - Jorg I
FAU - Harenberg, J
AU  - Harenberg J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Pathophysiol Haemost Thromb
JT  - Pathophysiology of haemostasis and thrombosis
JID - 101142710
RN  - 0 (Anticoagulants)
RN  - 0 (Azetidines)
RN  - 0 (Benzylamines)
RN  - 0 (Hirudins)
RN  - 0 (Pipecolic Acids)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Sulfonamides)
RN  - 2A9QP32MD4 (melagatran)
RN  - 9005-49-6 (Heparin)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 3.4.21.5 (Thrombin)
RN  - IY90U61Z3S (argatroban)
RN  - Q08SIO485D (Phenprocoumon)
RN  - TE7660XO1C (Glycine)
RN  - Y43GF64R34 (lepirudin)
SB  - IM
MH  - Anticoagulants/*blood/*pharmacology
MH  - Arginine/analogs & derivatives
MH  - Azetidines
MH  - Benzylamines
MH  - Drug Monitoring/*standards
MH  - Glycine/*analogs & derivatives/blood
MH  - Heparin/blood
MH  - Hirudins/*analogs & derivatives/blood
MH  - Humans
MH  - Partial Thromboplastin Time/standards
MH  - Phenprocoumon/*pharmacology
MH  - Pipecolic Acids/blood
MH  - Recombinant Proteins/blood
MH  - Reproducibility of Results
MH  - Sulfonamides
MH  - Thrombin/antagonists & inhibitors
MH  - Thrombophilia/*diagnosis/drug therapy
EDAT- 2003/05/22 05:00
MHDA- 2004/02/21 05:00
CRDT- 2003/05/22 05:00
PHST- 2002/05/03 00:00 [received]
PHST- 2002/10/30 00:00 [accepted]
PHST- 2003/05/22 05:00 [pubmed]
PHST- 2004/02/21 05:00 [medline]
PHST- 2003/05/22 05:00 [entrez]
AID - 70423 [pii]
AID - 10.1159/000070423 [doi]
PST - ppublish
SO  - Pathophysiol Haemost Thromb. 2002 Jul-Aug;32(4):174-9. doi: 10.1159/000070423.