PMID- 12760794
OWN - NLM
STAT- MEDLINE
DCOM- 20030908
LR  - 20061115
IS  - 0253-9624 (Print)
IS  - 0253-9624 (Linking)
VI  - 37
IP  - 1
DP  - 2003 Jan
TI  - [Role of hepatitis B virus infection in pathogenesis of IgA nephropathy].
PG  - 37-40
AB  - OBJECTIVE: To clarify the relationship between hepatitis B virus (HBV) infection 
      and IgA nephropathy (IgAN). METHODS: HBV antigen (HBAg) in renal tissues of the 
      patients with IgAN was detected by immunohistochemical technique, the carrier 
      status and localization of HBV DNA in renal tissues were determined by Southern 
      blot analysis and in situ hybridization. RESULTS: Serum HBsAg was detected in 18 
      of the 100 patients with IgAN (18%), HBAg was detected in 31 of 100 patients 
      (31%) in their renal tissue and in 20 of 31 patients (65%) in their glomeruli, 
      and both HBsAg and HBcAg were detected in 10 of 31 patients (32%), respectively. 
      HBcAg was also found in tubular epithelia (45%, 14/31) and renal interstitium 
      (6%, 2/31), respectively. Five of six cases were proved to be positive of 
      integrated-form HBV DNA in their renal tissue by Southern blot analysis. In situ 
      hybridization demonstrated that HBV DNA was 8/8 and 6/8 positive in their renal 
      tubules and glomeruli of all eight specimens, localized in the nucleus of tubular 
      epithelial cells, glomerular mesangial cells, as well as infiltrated interstitial 
      lymphocytes. CONCLUSION: HBV infection closely related with IgAN and HBV 
      infection might be involved in pathogenesis of IgAN.
FAU - Wang, Nian-song
AU  - Wang NS
AD  - Department of Nephrology, The Sixth People's Hospital of Shanghai, Shanghai 
      200233, China.
FAU - Wu, Zhao-long
AU  - Wu ZL
FAU - Zhang, Yue-e
AU  - Zhang YE
FAU - Guo, Mu-yi
AU  - Guo MY
FAU - Liao, Lu-tan
AU  - Liao LT
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yu Fang Yi Xue Za Zhi
JT  - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
JID - 7904962
RN  - 0 (Hepatitis B Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Glomerulonephritis, IGA/complications/*virology
MH  - Hepatitis B/*complications
MH  - Hepatitis B Antigens/*analysis
MH  - Hepatitis B virus/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2003/05/23 05:00
MHDA- 2003/09/10 05:00
CRDT- 2003/05/23 05:00
PHST- 2003/05/23 05:00 [pubmed]
PHST- 2003/09/10 05:00 [medline]
PHST- 2003/05/23 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Jan;37(1):37-40.