PMID- 12761967
OWN - NLM
STAT- MEDLINE
DCOM- 20040304
LR  - 20061115
IS  - 0412-3948 (Print)
IS  - 0412-3948 (Linking)
VI  - 36
IP  - 6
DP  - 2001 Dec
TI  - [Expression and significance of serum soluble tumor necrosis factor receptor-I in 
      patients with head and neck neoplasm].
PG  - 468-70
AB  - OBJECTIVE: To investigate the expression and significance of serum soluble tumor 
      necrosis factor receptor-I (sTNFR-I) in patients with head and neck neoplasms. 
      METHOD: The study was undertaken to detect serum sTNFR-I levels in 160 head neck 
      cancer patients (including 12 cases of malignant lymphoma, 62 nasopharyngeal 
      cancer, 56 laryngeal cancer, 22 hypopharyngeal cancer, 3 maxillary cancer and 5 
      thyrophyma), using Sandwich enzyme-linked immuno-sorbent assay. RESULTS: The 
      sTNFR-I levels were significantly higher in patients with carcinoma than those of 
      healthy controls (P < 0.01). The sTNFR-I levels of malignant lymphoma and 
      nasopharyngeal carcinoma were the highest among patients with head and neck 
      neoplasm. The correlations between the serum sTNFR-I levels and the stages of 
      head and neck neoplasms and other laboratory parameters were also analyzed and 
      discussed. CONCLUSION: The serum sTNFR-I levels may reflect the human immunity 
      function, therefore it can be used as a helpful indicator to evaluate the 
      therapeutic effect and monitor the relapses and metastasis of cancer.
FAU - Dong, W
AU  - Dong W
AD  - Department of Otorhinolaryngology, First Affiliated Hospital, Nanjing Medical 
      University, Nanjing 210029, China. dong weida@163.com
FAU - Xu, J
AU  - Xu J
FAU - Qiao, Z
AU  - Qiao Z
FAU - Wang, N
AU  - Wang N
FAU - Yu, R
AU  - Yu R
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Ke Za Zhi
JT  - Zhonghua er bi yan hou ke za zhi
JID - 16210350R
RN  - 0 (Receptors, Tumor Necrosis Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Head and Neck Neoplasms/*blood/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Receptors, Tumor Necrosis Factor/biosynthesis/*blood
EDAT- 2003/05/24 05:00
MHDA- 2004/03/05 05:00
CRDT- 2003/05/24 05:00
PHST- 2003/05/24 05:00 [pubmed]
PHST- 2004/03/05 05:00 [medline]
PHST- 2003/05/24 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001 Dec;36(6):468-70.