PMID- 12763607
OWN - NLM
STAT- MEDLINE
DCOM- 20030728
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 975
IP  - 1-2
DP  - 2003 Jun 13
TI  - Rapid induction of Arc is observed in the granule cell dendrites in the accessory 
      olfactory bulb after mating.
PG  - 189-95
AB  - The activity-regulated cytoskeleton-associated protein (Arc), encoded by the 
      immediate early gene arc, is enriched in the brain and is hypothesized to play a 
      role in the activity-dependent neuronal plasticity in the hippocampus. In the 
      present study, the time course of Arc expression during the post-mating period 
      was determined immunocytochemically, and the localization of Arc in the neurons 
      in the accessory olfactory bulb (AOB) of female mice after mating was analyzed 
      using immunocytochemical electron microscopy. Transient increases in the number 
      of Arc-immunoreactive cells were observed in the glomerular, mitral/tufted cell 
      and granule cell layers of the AOB after mating. In particular, the increase in 
      the granule cell layer was remarkable, and larger than the increases in the other 
      layers. In addition, electron microscopic observation revealed that Arc 
      immunoreactivity was in the dendrites of the granule cells 1.5 h after mating. 
      These results indicate that expression of Arc protein is induced rapidly and 
      transiently in granule cell dendrites after mating. It is postulated that Arc 
      protein has a role in the neuronal plasticity of the AOB after mating.
FAU - Matsuoka, Masato
AU  - Matsuoka M
AD  - Division of Neurobiology and Anatomy, Niigata University Graduate School of 
      Medical and Dental Sciences, Niigata, 1-757 Asahimachidori, Niigata 951-8510, 
      Japan. winner@med.niigata-u.ac.jp
FAU - Yoshida-Matsuoka, Junko
AU  - Yoshida-Matsuoka J
FAU - Yamagata, Kanato
AU  - Yamagata K
FAU - Sugiura, Hiroko
AU  - Sugiura H
FAU - Ichikawa, Masumi
AU  - Ichikawa M
FAU - Norita, Masao
AU  - Norita M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (activity regulated cytoskeletal-associated protein)
SB  - IM
MH  - Animals
MH  - Cytoplasmic Granules/physiology
MH  - Cytoskeletal Proteins/*biosynthesis
MH  - Dendrites/*metabolism/ultrastructure
MH  - Female
MH  - Immunohistochemistry
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microscopy, Electron
MH  - Nerve Tissue Proteins/*biosynthesis
MH  - Neuronal Plasticity/physiology
MH  - Olfactory Bulb/cytology/*metabolism/ultrastructure
MH  - Sexual Behavior, Animal/physiology
EDAT- 2003/05/24 05:00
MHDA- 2003/07/29 05:00
CRDT- 2003/05/24 05:00
PHST- 2003/05/24 05:00 [pubmed]
PHST- 2003/07/29 05:00 [medline]
PHST- 2003/05/24 05:00 [entrez]
AID - S0006899303026349 [pii]
AID - 10.1016/s0006-8993(03)02634-9 [doi]
PST - ppublish
SO  - Brain Res. 2003 Jun 13;975(1-2):189-95. doi: 10.1016/s0006-8993(03)02634-9.