PMID- 12765111
OWN - NLM
STAT- MEDLINE
DCOM- 20030829
LR  - 20190607
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 5
IP  - 2
DP  - 2003
TI  - Automated analysis of phase-contrast magnetic resonance images in the assessment 
      of endothelium-dependent flow-mediated dilation.
PG  - 325-32
AB  - Measurement of flow-mediated arterial dilation (FMAD) provides information 
      regarding the status of peripheral arterial endothelial function. Although 
      phase-contrast magnetic resonance imaging (PC-MRI) can be used to measure FMAD, 
      the manual analysis of one study (tracing regions of interest and processing data 
      on 100 images) can require six or more hours. To enhance the clinical utility of 
      the PC-MRI assessment of FMAD, we hypothesized that an automated technique 
      (Multi-Stage Intensity Thresholding or MSIT) for determining femoral arterial 
      area and flow before and after cuff inflation over the thigh could be used to 
      evaluate FMAD in a rapid, accurate, and reproducible manner. Compared with manual 
      analysis, automated analysis detected a similar percentage change in peak FMAD 
      between healthy individuals (17.2% vs 16.5%) and patients with congestive heart 
      failure (4.0% vs 5.1%). The correlation between percentage changes in arterial 
      area after cuff release derived manually and automatically was very good (r = 
      0.93). Analysis time for 100 images averaged 10 minutes with MSIT vs. 6 hours for 
      manual analysis. In conclusion, rapid, accurate assessments of femoral artery 
      FMAD can be obtained using Multi-Stage Intensity Thresholding. This methodology 
      may prove useful for the rapid MRI assessment of peripheral arterial endothelial 
      function in a clinical setting when studying patients with cardiovascular 
      disease.
FAU - Tan, Ping
AU  - Tan P
AD  - Department of Biomedical Engineering, Wake Forest University School of Medicine, 
      Winston-Salem, North Carolina, USA.
FAU - Hamilton, Craig A
AU  - Hamilton CA
FAU - Link, Kerry M
AU  - Link KM
FAU - Kitzman, Dalane W
AU  - Kitzman DW
FAU - Hundley, W Gregory
AU  - Hundley WG
LA  - eng
GR  - 3-M01-RR07122-08S1/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
SB  - IM
MH  - Algorithms
MH  - *Contrast Media
MH  - *Electronic Data Processing
MH  - Endothelium, Vascular/*diagnostic imaging/*physiology
MH  - Female
MH  - Femoral Artery/diagnostic imaging/physiology
MH  - Heart Failure/physiopathology
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Radiography
MH  - Reproducibility of Results
MH  - Statistics as Topic
MH  - Thigh/blood supply
MH  - Vasodilation/physiology
EDAT- 2003/05/27 05:00
MHDA- 2003/08/30 05:00
CRDT- 2003/05/27 05:00
PHST- 2003/05/27 05:00 [pubmed]
PHST- 2003/08/30 05:00 [medline]
PHST- 2003/05/27 05:00 [entrez]
AID - 10.1081/jcmr-120019416 [doi]
PST - ppublish
SO  - J Cardiovasc Magn Reson. 2003;5(2):325-32. doi: 10.1081/jcmr-120019416.