PMID- 12766327
OWN - NLM
STAT- MEDLINE
DCOM- 20030722
LR  - 20171101
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 77
IP  - 4
DP  - 2003 Apr
TI  - Thyrotropin-releasing hormone as a mediator of the central autonomic pathway 
      controlling ovarian function.
PG  - 273-81
AB  - We studied the effect of thyrotropin-releasing hormone (TRH) applied centrally on 
      the sympathetic activity of the ovary in female rats. Intracerebroventricular 
      (i.c.v.) administration of a dose of 25 ng/kg weight produced an increase in 
      noradrenaline (NA) content at the ovary after 5 days of hormone administration. 
      However, higher doses in a range up to 500 ng/kg weight decreased NA content at 
      the ovary. At the celiac ganglia (where the cell bodies of sympathetic neurons 
      projecting to the ovary originate) there was an accumulation of NA in spite of a 
      decrease in tyrosine hydroxylase activity (T-OH). After cold exposure, opposite 
      effects on T-OH activity and no effects on NA in ganglia and in ovary were 
      obtained. Besides, i.v. injection of TRH only induced a decrease in ovarian NA. 
      In contrast to the increase in T(3) plasma levels obtained after the cold-stress 
      procedure, none of the i.c.v. doses of TRH used produced changes in T(3) plasma 
      levels, strongly suggesting that the effect on sympathetic activity is mediated 
      by a central effect of TRH acting as a putative activator of ovarian sympathetic 
      nerves.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Luza, S M
AU  - Luza SM
AD  - Laboratory of Neurobiochemistry, Department of Biochemistry and Molecular 
      Biology, Faculty of Chemistry, Santiago, Chile.
FAU - Arancibia, S
AU  - Arancibia S
FAU - Venegas, M
AU  - Venegas M
FAU - Lara, H E
AU  - Lara HE
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenal Glands/metabolism
MH  - Animals
MH  - Autonomic Pathways/*metabolism
MH  - Cold Temperature
MH  - Female
MH  - Ganglia, Sympathetic/metabolism
MH  - Norepinephrine/metabolism
MH  - Ovary/*innervation/metabolism
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Rats
MH  - Sympathetic Fibers, Postganglionic/metabolism
MH  - Thyrotropin-Releasing Hormone/*physiology
EDAT- 2003/05/27 05:00
MHDA- 2003/07/23 05:00
CRDT- 2003/05/27 05:00
PHST- 2002/08/14 00:00 [received]
PHST- 2003/01/31 00:00 [accepted]
PHST- 2003/05/27 05:00 [pubmed]
PHST- 2003/07/23 05:00 [medline]
PHST- 2003/05/27 05:00 [entrez]
AID - 70282 [pii]
AID - 10.1159/000070282 [doi]
PST - ppublish
SO  - Neuroendocrinology. 2003 Apr;77(4):273-81. doi: 10.1159/000070282.