PMID- 12766932
OWN - NLM
STAT- MEDLINE
DCOM- 20031126
LR  - 20141120
IS  - 0885-6222 (Print)
IS  - 0885-6222 (Linking)
VI  - 18
IP  - 4
DP  - 2003 Jun
TI  - Switching to tianeptine in patients with antidepressant-induced sexual 
      dysfunction.
PG  - 277-80
AB  - Sexual side effects are frequent and are recently being considered as effects of 
      antidepressant treatment. One method to improve the sexual dysfunction associated 
      with the use of antidepressants is to change to another antidepressant. In the 
      present work, the consequences of switching to tianeptine in patients with 
      antidepressant-induced sexual dysfunction were studied. The study group comprised 
      23 patients with major depressive disorder who experienced antidepressant-induced 
      sexual dysfunction. These antidepressants were stopped and switched to tianeptine 
      (12.5mg x 3/day). All patients were screened by using the clinical global 
      impression-improvement scale (CGI-I), the Hamilton depression rating scale 
      (HAM-D) and the Arizona sexual experience scale (ASEX) at the beginning of the 
      study, and at weeks 4 and 8. No patient failed to tolerate 37.5mg of tianeptine 
      or to complete the study except for one patient becoming pregnant. Paired t-tests 
      revealed a significant difference between baseline and week 4 or week 8 in scores 
      on both the HAM-D and ASEX. At 8 weeks, six patients were rated as very much 
      improved (CGI-I=1) and ten patients were rated as much improved (CGI-I=2). Thus, 
      with a CGI-I score of 2 or less used to indicate a positive response, 72.7% of 
      the patients were responders. The results suggest that switching to tianeptine 
      appears to be useful for alleviating sexual dysfunction caused by other 
      antidepressants.
CI  - Copyright 2003 John Wiley & Sons, Ltd.
FAU - Atmaca, Murad
AU  - Atmaca M
AD  - Firat University, School of Medicine, Department of Psychiatry, Elazig, Turkey. 
      matmaca_p@yahoo.com
FAU - Kuloglu, Murat
AU  - Kuloglu M
FAU - Tezcan, Ertan
AU  - Tezcan E
FAU - Buyukbayram, Ayten
AU  - Buyukbayram A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Hum Psychopharmacol
JT  - Human psychopharmacology
JID - 8702539
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antidepressive Agents, Tricyclic)
RN  - 0 (Thiazepines)
RN  - 0T493YFU8O (tianeptine)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/*adverse effects/*therapeutic use
MH  - Antidepressive Agents, Tricyclic/therapeutic use
MH  - Depressive Disorder/drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Sexual Dysfunctions, Psychological/*chemically induced
MH  - Thiazepines/*therapeutic use
EDAT- 2003/05/27 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/05/27 05:00
PHST- 2003/05/27 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/05/27 05:00 [entrez]
AID - 10.1002/hup.479 [doi]
PST - ppublish
SO  - Hum Psychopharmacol. 2003 Jun;18(4):277-80. doi: 10.1002/hup.479.