PMID- 12767132
OWN - NLM
STAT- MEDLINE
DCOM- 20031009
LR  - 20030527
IS  - 0095-2338 (Print)
IS  - 0095-2338 (Linking)
VI  - 43
IP  - 3
DP  - 2003 May-Jun
TI  - Text Influenced Molecular Indexing (TIMI): a literature database mining approach 
      that handles text and chemistry.
PG  - 743-52
AB  - We present an application of a novel methodology called Text Influenced Molecular 
      Indexing (TIMI) to mine the information in the scientific literature. TIMI is an 
      extension of two existing methodologies: (1) Latent Semantic Structure Indexing 
      (LaSSI), a method for calculating chemical similarity using two-dimensional 
      topological descriptors, and (2) Latent Semantic Indexing (LSI), a method for 
      generating correlations between textual terms. The singular value decomposition 
      (SVD) of a feature/object matrix is the fundamental mathematical operation 
      underlying LSI, LaSSI, and TIMI and is used in the identification of associations 
      between textual and chemical descriptors. We present the results of our studies 
      with a database containing 11,571 PubMed/MEDLINE abstracts which show the 
      advantages of merging textual and chemical descriptors over using either text or 
      chemistry alone. Our work demonstrates that searching text-only databases limits 
      retrieved documents to those that explicitly mention compounds by name in the 
      text. Similarly, searching chemistry-only databases can only retrieve those 
      documents that have chemical structures in them. TIMI, however, enables search 
      and retrieval of documents with textual, chemical, and/or text- and 
      chemistry-based queries. Thus, the TIMI system offers a powerful new approach to 
      uncovering the contextual scientific knowledge sought by the medical research 
      community.
FAU - Singh, Suresh B
AU  - Singh SB
AD  - Department of Molecular Systems, Merck Research Laboratories, 126 East Lincoln 
      Avenue, RY50SW-100, Rahway, New Jersey 07065-0900, USA. singhsu@yahoo.com
FAU - Hull, Richard D
AU  - Hull RD
FAU - Fluder, Eugene M
AU  - Fluder EM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Chem Inf Comput Sci
JT  - Journal of chemical information and computer sciences
JID - 7505012
RN  - 0 (Organic Chemicals)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Algorithms
MH  - Chemistry, Pharmaceutical/methods
MH  - *Databases, Factual
MH  - MEDLINE
MH  - *Organic Chemicals
MH  - *Pharmaceutical Preparations
MH  - *Subject Headings
EDAT- 2003/05/28 05:00
MHDA- 2003/10/10 05:00
CRDT- 2003/05/28 05:00
PHST- 2003/05/28 05:00 [pubmed]
PHST- 2003/10/10 05:00 [medline]
PHST- 2003/05/28 05:00 [entrez]
AID - 10.1021/ci025587a [doi]
PST - ppublish
SO  - J Chem Inf Comput Sci. 2003 May-Jun;43(3):743-52. doi: 10.1021/ci025587a.