PMID- 12767478
OWN - NLM
STAT- MEDLINE
DCOM- 20030725
LR  - 20190916
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 46
IP  - 2
DP  - 2003 Jun
TI  - The effects of dentate granule cell destruction on behavioral activity and Fos 
      protein expression induced by systemic MDMA in rats.
PG  - 153-60
AB  - In this study, we examined the effect of the s.c. administration of (+/-) 
      3,4-methylenedioxymethamphetamine (MDMA) or saline on locomotor activity and Fos 
      expression following the bilateral destruction of hippocampal dentate granule 
      cells by colchicine in rats. The lesioned animals, when administered s.c. saline, 
      showed a significantly greater increase in locomotor activity compared to the 
      intact animals, and revealed a marginally significant level of increased 
      locomotor activity compared to the sham-lesioned animals. In addition, when the 
      lesioned animals were given s.c. saline or MDMA, there was a significant increase 
      in Fos expression in the nucleus accumbens core, but not in the medial prefrontal 
      cortex, dorsolateral prefrontal cortex, anterior cingulate cortex, piriform 
      cortex, dorsal striatum, or nucleus accumbens shell, compared to the intact and 
      sham-lesioned animals. Overall, these results suggest that the nucleus accumbens 
      core may be involved in the enhancement of locomotor activity induced by the 
      injection of saline alone (stress loading) or MDMA following bilateral 
      destruction of hippocampal dentate granule cells by colchicine.
FAU - Won, Mujun
AU  - Won M
AD  - Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 
      Shizuoka 431-3192, Japan.
FAU - Minabe, Yoshio
AU  - Minabe Y
FAU - Tani, Kunihiko
AU  - Tani K
FAU - Suzuki, Katsuaki
AU  - Suzuki K
FAU - Kawai, Masayoshi
AU  - Kawai M
FAU - Sekine, Yoshimoto
AU  - Sekine Y
FAU - Ashby, Charles R Jr
AU  - Ashby CR Jr
FAU - Takei, Nori
AU  - Takei N
FAU - Mori, Norio
AU  - Mori N
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Hallucinogens)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - SML2Y3J35T (Colchicine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain/*drug effects/metabolism/pathology
MH  - Colchicine/administration & dosage/toxicity
MH  - Dentate Gyrus/drug effects/metabolism/pathology
MH  - Hallucinogens/*pharmacology
MH  - Immunohistochemistry
MH  - Injections, Intraventricular
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neurons/*drug effects/metabolism/pathology
MH  - Proto-Oncogene Proteins c-fos/biosynthesis/*drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2003/05/28 05:00
MHDA- 2003/07/26 05:00
CRDT- 2003/05/28 05:00
PHST- 2003/05/28 05:00 [pubmed]
PHST- 2003/07/26 05:00 [medline]
PHST- 2003/05/28 05:00 [entrez]
AID - S0168010203000415 [pii]
AID - 10.1016/s0168-0102(03)00041-5 [doi]
PST - ppublish
SO  - Neurosci Res. 2003 Jun;46(2):153-60. doi: 10.1016/s0168-0102(03)00041-5.