PMID- 12768761
OWN - NLM
STAT- MEDLINE
DCOM- 20040330
LR  - 20061115
IS  - 0412-3948 (Print)
IS  - 0412-3948 (Linking)
VI  - 35
IP  - 6
DP  - 2000 Dec
TI  - [Basement membrane in squamous cell carcinomas of the larynx: an 
      immunohistochemical study].
PG  - 457-60
AB  - OBJECTIVE: The study was to assess the distribution of basement membrane(BM) in 
      laryngeal squamous cell carcinomas(LSCC). Correlation of BM and clinical 
      parameters (TNM stage, histological grading, invasion mode, lymph node 
      metastasis) was also examined. METHODS: The expression of BM around tumor cell 
      was determined in 40 cases of LSCC by using monoclonal antibody against human 
      type IV collagen. An intact continuous BM was found in 17 cases (42.5%), while 
      partial or widespread loss of the BM was detected in the other 23 cases (57.5%). 
      RESULTS: In cases with poor histological differentiation, the defect of BM was 
      more severe than that in cases with high or middle histological differentiation 
      (P < 0.05). Moreover, diffuse invasion carcinomas revealed lower type IV collagen 
      expression comparing with cases with better tumor-host border (P < 0.05). There 
      was a higher risk of regional lymph node metastasis among cases with poor BM 
      expression (P < 0.01), but there was no association of clinical stage with BM 
      defect (P > 0.05). CONCLUSION: These observations indicated that testing the 
      distribution of BM seems to be useful to evaluate the histological grading of 
      malignancy of laryngeal carcinoma and be helpful to prognosticate the frequency 
      of regional lymph node metastasis.
FAU - Cao, Z
AU  - Cao Z
AD  - Department of Otorhinolaryngology, First Clinical Hospital, China Medical 
      University, Shenyang 110001, China. zhiweicao@hotmail.com
FAU - Wang, Y
AU  - Wang Y
FAU - Ren, Z
AU  - Ren Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Ke Za Zhi
JT  - Zhonghua er bi yan hou ke za zhi
JID - 16210350R
RN  - 0 (Collagen Type IV)
SB  - IM
MH  - Aged
MH  - Basement Membrane/*chemistry
MH  - Carcinoma, Squamous Cell/*chemistry/secondary
MH  - Collagen Type IV/analysis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*chemistry/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
EDAT- 2003/05/29 05:00
MHDA- 2004/03/31 05:00
CRDT- 2003/05/29 05:00
PHST- 2003/05/29 05:00 [pubmed]
PHST- 2004/03/31 05:00 [medline]
PHST- 2003/05/29 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Ke Za Zhi. 2000 Dec;35(6):457-60.