PMID- 12769348
OWN - NLM
STAT- MEDLINE
DCOM- 20031205
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 44
IP  - 4
DP  - 2003 Apr
TI  - Mutations in the retinoblastoma-related gene RB2/p130 in adult T-cell 
      leukaemia/lymphoma.
PG  - 699-701
AB  - The retinoblastoma (Rb) family consists of the tumor suppressor Rb/p105 and 
      related proteins p107 and Rb2/p130. Although the involvement of the RB/p105 gene 
      in Adult T-cell leukaemia/lymphoma (ATL) has been studied, no mutational data is 
      reported regarding the RB2/p130 gene in ATL. We screened for mutations of the 
      RB2/p130 gene. Mutation was detected in 1 of 41 primary ATL sample. This is the 
      first report describing mutation of the RB2/p130 gene in ATL, suggesting that 
      RB2/p130 may be involved in the development of ATL, and may behave as a tumor 
      suppressor gene in T lymphocytes.
FAU - Takeuchi, Seisho
AU  - Takeuchi S
AD  - Department of Internal Medicine, Kochi Medical School, Okohcho, Nankoku, Kochi 
      783-8505, Japan. takeuti@kochi-ms.ac.jp
FAU - Takeuchi, Naoko
AU  - Takeuchi N
FAU - Tsukasaki, Kunihiro
AU  - Tsukasaki K
FAU - Fermin, Anthony C
AU  - Fermin AC
FAU - De Vas, Sven
AU  - De Vas S
FAU - Seo, Hiromi
AU  - Seo H
FAU - Koeffler, H Phillip
AU  - Koeffler HP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Phosphoproteins)
RN  - 0 (Proteins)
RN  - 0 (RBL2 protein, human)
RN  - 0 (Retinoblastoma-Like Protein p130)
SB  - IM
MH  - Cell Cycle
MH  - DNA Mutational Analysis
MH  - Exons
MH  - Humans
MH  - Leukemia, T-Cell/*genetics
MH  - Lymphoma/*genetics
MH  - *Mutation
MH  - Phosphoproteins/*genetics
MH  - Point Mutation
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single-Stranded Conformational
MH  - *Proteins
MH  - Retinoblastoma-Like Protein p130
MH  - T-Lymphocytes/metabolism
EDAT- 2003/05/29 05:00
MHDA- 2003/12/06 05:00
CRDT- 2003/05/29 05:00
PHST- 2003/05/29 05:00 [pubmed]
PHST- 2003/12/06 05:00 [medline]
PHST- 2003/05/29 05:00 [entrez]
AID - 10.1080/1042819031000063480 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2003 Apr;44(4):699-701. doi: 10.1080/1042819031000063480.