PMID- 12770790
OWN - NLM
STAT- MEDLINE
DCOM- 20040211
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 6
DP  - 2003 Jun
TI  - Differential immunogenicity of paternal HLA Class I antigens in pregnant women.
PG  - 600-6
AB  - More insight into the differential immunogenicity of human leukocyte antigen 
      (HLA) mismatches will be beneficial for donor selection in clinical 
      transplantation. In this study the immunogenicity of HLA antigens was analyzed by 
      examining the antibody profiles in women who have been pregnant. In total 888 
      women, who had pregnancy induced HLA alloantibodies, were included in this study, 
      while 413 women who had not been immunized by their pregnancy, served as 
      controls. First it was analyzed whether women expressing particular HLA antigens 
      are more likely to produce HLA alloantibodies. Next we determined whether certain 
      HLA mismatches of their children are more immunogenic than other ones. Finally we 
      studied whether the immunogenicity of specific HLA mismatches is dependent on the 
      HLA phenotype of the women. Women expressing HLA-A3, HLA-A32, and HLA-B21 are 
      more likely to produce alloantibodies whereas women expressing HLA-B13 and 
      HLA-B17 have a significantly lower incidence of alloantibodies compared with 
      women expressing other HLA antigens. Children with HLA-A2 or HLA-B5 mismatches 
      induced alloantibodies significantly more often whereas children with HLA-A30, 
      -A31 or -A33 and HLA-A28 induced alloantibodies significantly less often than 
      children with other HLA class I mismatches. Finally we could demonstrate that the 
      immunogenicity of a particular HLA mismatch is dependent on the HLA phenotype of 
      the women. Information on the differential immunogenicity of HLA mismatches may 
      be of benefit for the determination of acceptable and taboo mismatches in the 
      case of donor selection for (highly sensitized) patients.
FAU - Dankers, Marlies K A
AU  - Dankers MK
AD  - Department of Immunohematology & Blood Transfusion, Leiden University Medical 
      Center, Leiden, The Netherlands. m.k.a.dankers@lumc.nl
FAU - Roelen, Dave L
AU  - Roelen DL
FAU - Korfage, Nelleke
AU  - Korfage N
FAU - de Lange, Peter
AU  - de Lange P
FAU - Witvliet, Marian
AU  - Witvliet M
FAU - Sandkuijl, Lodewijk
AU  - Sandkuijl L
FAU - Doxiadis, Ilias I N
AU  - Doxiadis II
FAU - Claas, Frans H J
AU  - Claas FH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Female
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Humans
MH  - Isoantibodies/*immunology
MH  - Phenotype
MH  - Pregnancy
EDAT- 2003/05/29 05:00
MHDA- 2004/02/12 05:00
CRDT- 2003/05/29 05:00
PHST- 2003/05/29 05:00 [pubmed]
PHST- 2004/02/12 05:00 [medline]
PHST- 2003/05/29 05:00 [entrez]
AID - S0198885903000582 [pii]
AID - 10.1016/s0198-8859(03)00058-2 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Jun;64(6):600-6. doi: 10.1016/s0198-8859(03)00058-2.