PMID- 12771210
OWN - NLM
STAT- MEDLINE
DCOM- 20030630
LR  - 20190501
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 31
IP  - 11
DP  - 2003 Jun 1
TI  - SPINE 2: a system for collaborative structural proteomics within a federated 
      database framework.
PG  - 2833-8
AB  - We present version 2 of the SPINE system for structural proteomics. SPINE is 
      available over the web at http://nesg.org. It serves as the central hub for the 
      Northeast Structural Genomics Consortium, allowing collaborative structural 
      proteomics to be carried out in a distributed fashion. The core of SPINE is a 
      laboratory information management system (LIMS) for key bits of information 
      related to the progress of the consortium in cloning, expressing and purifying 
      proteins and then solving their structures by NMR or X-ray crystallography. 
      Originally, SPINE focused on tracking constructs, but, in its current form, it is 
      able to track target sample tubes and store detailed sample histories. The core 
      database comprises a set of standard relational tables and a data dictionary that 
      form an initial ontology for proteomic properties and provide a framework for 
      large-scale data mining. Moreover, SPINE sits at the center of a federation of 
      interoperable information resources. These can be divided into (i) local 
      resources closely coupled with SPINE that enable it to handle less standardized 
      information (e.g. integrated mailing and publication lists), (ii) other 
      information resources in the NESG consortium that are inter-linked with SPINE 
      (e.g. crystallization LIMS local to particular laboratories) and (iii) 
      international archival resources that SPINE links to and passes on information to 
      (e.g. TargetDB at the PDB).
FAU - Goh, Chern-Sing
AU  - Goh CS
AD  - Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New 
      Haven, CT 06520, USA.
FAU - Lan, Ning
AU  - Lan N
FAU - Echols, Nathaniel
AU  - Echols N
FAU - Douglas, Shawn M
AU  - Douglas SM
FAU - Milburn, Duncan
AU  - Milburn D
FAU - Bertone, Paul
AU  - Bertone P
FAU - Xiao, Rong
AU  - Xiao R
FAU - Ma, Li-Chung
AU  - Ma LC
FAU - Zheng, Deyou
AU  - Zheng D
FAU - Wunderlich, Zeba
AU  - Wunderlich Z
FAU - Acton, Tom
AU  - Acton T
FAU - Montelione, Gaetano T
AU  - Montelione GT
FAU - Gerstein, Mark
AU  - Gerstein M
LA  - eng
GR  - P50 GM062413/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 0 (Proteins)
SB  - IM
MH  - Cooperative Behavior
MH  - Database Management Systems
MH  - *Databases, Protein
MH  - Internet
MH  - Proteins/*chemistry/genetics/isolation & purification/metabolism
MH  - *Proteomics
MH  - Software
MH  - Systems Integration
PMC - PMC156730
EDAT- 2003/05/29 05:00
MHDA- 2003/07/02 05:00
PMCR- 2003/06/01
CRDT- 2003/05/29 05:00
PHST- 2003/05/29 05:00 [pubmed]
PHST- 2003/07/02 05:00 [medline]
PHST- 2003/05/29 05:00 [entrez]
PHST- 2003/06/01 00:00 [pmc-release]
AID - gkg397 [pii]
AID - 10.1093/nar/gkg397 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2003 Jun 1;31(11):2833-8. doi: 10.1093/nar/gkg397.