PMID- 12773773
OWN - NLM
STAT- MEDLINE
DCOM- 20040217
LR  - 20161124
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 74
IP  - 2
DP  - 2003 Aug
TI  - Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: 
      maternal and prenatal evaluations.
PG  - 369-81
AB  - The maternal and developmental toxicities of perfluorooctane sulfonate (PFOS, 
      C8F17SO3-) were evaluated in the rat and mouse. PFOS is an environmentally 
      persistent compound used as a surfactant and occurs as a degradation product of 
      both perfluorooctane sulfonyl fluoride and substituted perfluorooctane 
      sulfonamido components found in many commercial and consumer applications. 
      Pregnant Sprague-Dawley rats were given 1, 2, 3, 5, or 10 mg/kg PFOS daily by 
      gavage from gestational day (GD) 2 to GD 20; CD-1 mice were similarly treated 
      with 1, 5, 10, 15, and 20 mg/kg PFOS from GD 1 to GD 17. Controls received 0.5% 
      Tween-20 vehicle (1 ml/kg for rats and 10 ml/kg for mice). Maternal weight gain, 
      food and water consumption, and serum chemistry were monitored. Rats were 
      euthanized on GD 21 and mice on GD 18. PFOS levels in maternal serum and in 
      maternal and fetal livers were determined. Maternal weight gains in both species 
      were suppressed by PFOS in a dose-dependent manner, likely attributed to reduced 
      food and water intake. Serum PFOS levels increased with dosage, and liver levels 
      were approximately fourfold higher than serum. Serum thyroxine (T4) and 
      triiodothyronine (T3) in the PFOS-treated rat dams were significantly reduced as 
      early as one week after chemical exposure, although no feedback response of 
      thyroid-stimulating hormone (TSH) was observed. A similar pattern of reduction in 
      T4 was also seen in the pregnant mice. Maternal serum triglycerides were 
      significantly reduced, particularly in the high-dose groups, although cholesterol 
      levels were not affected. In the mouse dams, PFOS produced a marked enlargement 
      of the liver at 10 mg/kg and higher dosages. In the rat fetuses, PFOS was 
      detected in the liver but at levels nearly half of those in the maternal 
      counterparts, regardless of administered doses. In both rodent species, PFOS did 
      not alter the numbers of implantations or live fetuses at term, although small 
      deficits in fetal weight were noted in the rat. A host of birth defects, 
      including cleft palate, anasarca, ventricular septal defect, and enlargement of 
      the right atrium, were seen in both rats and mice, primarily in the 10 and 20 
      mg/kg dosage groups, respectively. Our results demonstrate both maternal and 
      developmental toxicity of PFOS in the rat and mouse.
FAU - Thibodeaux, Julie R
AU  - Thibodeaux JR
AD  - Reproductive Toxicology Division, National Health and Environmental Effects 
      Research Laboratory, Office of Research and Development, U.S. Environmental 
      Protection Agency, Research Triangle Park, North Carolina 27711, USA.
FAU - Hanson, Roger G
AU  - Hanson RG
FAU - Rogers, John M
AU  - Rogers JM
FAU - Grey, Brian E
AU  - Grey BE
FAU - Barbee, Brenda D
AU  - Barbee BD
FAU - Richards, Judy H
AU  - Richards JH
FAU - Butenhoff, John L
AU  - Butenhoff JL
FAU - Stevenson, Lisa A
AU  - Stevenson LA
FAU - Lau, Christopher
AU  - Lau C
LA  - eng
PT  - Journal Article
DEP - 20030528
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Teratogens)
RN  - 0 (Triglycerides)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
EIN - Toxicol Sci. 2004 Nov;82(1):359
MH  - *Abnormalities, Drug-Induced
MH  - Administration, Oral
MH  - Alkanesulfonic Acids/administration & dosage/pharmacokinetics/*toxicity
MH  - Animals
MH  - Body Weight/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drinking/drug effects
MH  - Eating/drug effects
MH  - Female
MH  - Fetal Weight/drug effects
MH  - Fetus/drug effects/metabolism
MH  - Fluorocarbons/administration & dosage/pharmacokinetics/*toxicity
MH  - Liver/drug effects/pathology
MH  - *Maternal Exposure
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Organ Size/drug effects
MH  - Pregnancy/blood
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction/*drug effects
MH  - Teratogens/pharmacokinetics/*toxicity
MH  - Thyroxine/blood
MH  - Triglycerides/blood
MH  - Triiodothyronine/blood
EDAT- 2003/05/30 05:00
MHDA- 2004/02/18 05:00
CRDT- 2003/05/30 05:00
PHST- 2003/05/30 05:00 [pubmed]
PHST- 2004/02/18 05:00 [medline]
PHST- 2003/05/30 05:00 [entrez]
AID - kfg121 [pii]
AID - 10.1093/toxsci/kfg121 [doi]
PST - ppublish
SO  - Toxicol Sci. 2003 Aug;74(2):369-81. doi: 10.1093/toxsci/kfg121. Epub 2003 May 28.