PMID- 12776444
OWN - NLM
STAT- MEDLINE
DCOM- 20030916
LR  - 20191210
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 24
IP  - 2
DP  - 2003 Mar-Apr
TI  - Relationship between the tumor necrosis factor system and the serum 
      interleukin-4, interleukin-5, interleukin-8, eosinophil cationic protein, and 
      immunoglobulin E levels in the bronchial hyperreactivity of adults and their 
      children.
PG  - 111-8
AB  - The aim of the study was to investigate the activation of inflammatory mediators 
      interleukin (IL)-4, IL-5, and IL-8; immunoglobulin E (IgE); and eosinophil 
      cationic protein (ECP) and to evaluate the regulatory role of the tumor necrosis 
      system (TNF) system in bronchial hyperreactivity. Adults who had suffered from 
      bronchial asthma in childhood but who had been symptom free for at least 3 years 
      were examined together with their children who did not have asthma. The serum 
      concentrations of TNF-alpha, soluble TNF receptor 1 (sTNF-R1), TNF-R2, IL-4, 
      IL-5, IL-8, ECP, and IgE were studied in symptom-free adults (n = 22) and their 
      children (n = 22) with bronchial hyperreactivity. Nonhyperreactive individuals 
      with a similar medical history (adults, n = 17; children, n = 20) served as 
      controls. Significantly elevated serum TNF-alpha (X +/- SD: 5.13 +/- 1.37 pg/mL 
      versus 3.91 +/- 0.61 pg/mL; p < 0.0001), sTNF-R1 (X +/- SD: 1.37 +/- 0.28 ng/mL 
      versus 1.16 +/- 0.13 ng/mL; p = 0.0002), and sTNF-R2 (X +/- SD: 0.78 +/- 0.42 
      ng/mL versus 0.43 +/- 0.41 ng/mL; p = 0.0001); IL-4 (X +/- SD: 4.05 +/- 1.02 
      pg/mL versus 3.34 +/- 0.84 pg/mL; p = 0.0016); IgE (X +/- SD: 390.1 +/- 361.4 
      KU/L versus 130.2 +/- 166.1 KU/L; p = 0.0001); and ECP (X +/- SD: 17.57 +/- 11.03 
      micrograms/L versus 10.65 +/- 6.01 micrograms/L; p = 0.0016) concentrations were 
      measured in the subjects with bronchial hyperreactivity as compared with the 
      nonhyperreactive group. Significant positive linear correlations were observed 
      for the bronchial hyperreactive group between the concentrations of TNF-alpha and 
      ECP, TNF-alpha and sTNF-R1, TNF-alpha and IL-8, sTNF-R1 and ECP, sTNF-R1 and 
      IL-8, and sTNF-R2 and IL-8. Moreover, the TNF-alpha and sTNF-R2 levels correlated 
      with the airway reactivity in the hyperreactive group. We suggest that the 
      elevated cytokine levels indicate activation of the immune system in individuals 
      who were previously asthmatic, but recovered, and are now symptom free and in 
      their children with nonasthmatic bronchial hyperreactivity. The TNF system may 
      play a key role in the pathomechanism of bronchial hyperreactivity.
FAU - Halasz, A
AU  - Halasz A
AD  - First Department of Pediatrics, Semmelweis Medical University, Svabhegy 
      Children's Hospital, Budapest.
FAU - Cserhati, E
AU  - Cserhati E
FAU - Kosa, L
AU  - Kosa L
FAU - Cseh, K
AU  - Cseh K
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Biomarkers)
RN  - 0 (Blood Proteins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-5)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Proteins/*metabolism
MH  - Child
MH  - Eosinophil Granule Proteins
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Humans
MH  - Hungary
MH  - Immunoglobulin E/*blood
MH  - Inflammation Mediators/blood
MH  - Interleukin-4/*blood
MH  - Interleukin-5/*blood
MH  - Interleukin-8/*blood
MH  - Male
MH  - Parent-Child Relations
MH  - *Ribonucleases
MH  - Spirometry
MH  - Tumor Necrosis Factor-alpha/metabolism/*physiology
EDAT- 2003/06/05 05:00
MHDA- 2003/09/17 05:00
CRDT- 2003/06/05 05:00
PHST- 2003/06/05 05:00 [pubmed]
PHST- 2003/09/17 05:00 [medline]
PHST- 2003/06/05 05:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2003 Mar-Apr;24(2):111-8.