PMID- 12776910
OWN - NLM
STAT- MEDLINE
DCOM- 20030827
LR  - 20131121
IS  - 0004-069X (Print)
IS  - 0004-069X (Linking)
VI  - 51
IP  - 2
DP  - 2003
TI  - The dynamic and complex role of mast cells in allergic disease.
PG  - 111-20
AB  - Mast cells (MCs) are found widely distributed in tissues and contribute to 
      regulation of inflammatory responses and ongoing modulation of the tissues. 
      Although MCs are important in a variety of processes, including innate immunity, 
      their role in allergic disease has received increasing attention in the past 
      decade. MCs are located throughout the human body and, upon allergen exposure, 
      they are stimulated via the immunoglobulin E (IgE) receptor (Fc(epsilon)RI) to 
      release several pro-inflammatory mediators such as tumor necrosis factor (TNF), 
      reactive oxygen species such as nitric oxide (NO), proteases, and lipid-derived 
      mediators. However, we now recognize that MCs can be activated by a variety of 
      mechanisms and that mediator release is a consequence of several intra- and 
      extracellular signals. Some of these mechanisms, such as Fc receptor aggregation 
      and proteinase-activated receptor (PAR)-mediated activation facilitate and 
      augment local inflammatory responses. Other mechanisms, such as interferon gamma 
      (IFN-gamma) induction of NO, may inhibit MC function and downregulate 
      inflammatory responses. Increased understanding of these complex pathways has 
      encouraged the development of therapies for allergic inflammation that target 
      specific MC functions and mediators. Some novel strategies include 
      oligonucleotides that induce or inhibit the production of specific mediators. 
      Such approaches may yield useful therapies for allergic individuals in the near 
      future.
FAU - Kulka, Marianna
AU  - Kulka M
AD  - Pulmonary Research Group, 550A HMRC, University of Alberta, Edmonton, T6G 2S2, 
      Canada.
FAU - Befus, A Dean
AU  - Befus AD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Arch Immunol Ther Exp (Warsz)
JT  - Archivum immunologiae et therapiae experimentalis
JID - 0114365
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Cytokines/physiology
MH  - Histamine/immunology
MH  - Humans
MH  - Hypersensitivity/*immunology/therapy
MH  - Inflammation Mediators/physiology
MH  - Mast Cells/*immunology
MH  - Models, Immunological
RF  - 79
EDAT- 2003/06/05 05:00
MHDA- 2003/08/28 05:00
CRDT- 2003/06/05 05:00
PHST- 2003/06/05 05:00 [pubmed]
PHST- 2003/08/28 05:00 [medline]
PHST- 2003/06/05 05:00 [entrez]
PST - ppublish
SO  - Arch Immunol Ther Exp (Warsz). 2003;51(2):111-20.