PMID- 12778750
OWN - NLM
STAT- MEDLINE
DCOM- 20040419
LR  - 20131121
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 38
IP  - 2
DP  - 2003 Feb
TI  - [Preparation of cisplatin multivesicular liposomes and release of cisplatin from 
      the liposomes in vitro].
PG  - 133-7
AB  - AIM: To prepare cisplatin multivesicular liposomes with high encapsulation 
      efficiency and sustained-release character, and compare the release 
      characteristics with conventional liposomes prepared by reverse-phase evaporation 
      method. METHODS: Cisplatin multivesicular liposomes were prepared using multiple 
      emulsion method. The concentrations of cisplatin and lipids in the liposomes were 
      measured by flameless atomic absorbance spectroscopy (FAAS) and phosphalipid 
      enzyme reagent method, respectively. The encapsulation efficiency, size and 
      release of the cisplatin from the liposomes were studied in vitro. RESULTS: The 
      mean diameter of cisplatin multivesicular liposomes was (16.6 +/- 1.0) micron. 
      The encapsulation efficiency of cisplatin was more than 80%. The release profile 
      in vitro fitted with a first-order equation. The releasing t1/2 of cisplatin 
      multivesicular liposomes is 37.7 h, which is 8.4 that of conventional liposomes. 
      Co-membrane stabilizer has remarkable stabilizing effect on the multivesicular 
      liposomal membrane confirmed by differential scattering calorimetry (DSC). 
      CONCLUSION: The cisplatin multivesicular liposomes showed high encapsulation 
      efficiency and sustained-release character.
FAU - Xiao, Chao-ju
AU  - Xiao CJ
AD  - Department of Pharmaceutics, School of Pharmaceutical Science, Peking University, 
      Beijing 100083, China.
FAU - Qi, Xian-rong
AU  - Qi XR
FAU - Aini, Waer
AU  - Aini W
FAU - Wei, Shu-li
AU  - Wei SL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Carriers)
RN  - 0 (Liposomes)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Antineoplastic Agents/*administration & dosage/analysis
MH  - Cisplatin/*administration & dosage/analysis
MH  - *Delayed-Action Preparations
MH  - Drug Carriers
MH  - *Drug Delivery Systems
MH  - Liposomes
MH  - Particle Size
MH  - Technology, Pharmaceutical/methods
EDAT- 2003/06/05 05:00
MHDA- 2004/04/20 05:00
CRDT- 2003/06/05 05:00
PHST- 2003/06/05 05:00 [pubmed]
PHST- 2004/04/20 05:00 [medline]
PHST- 2003/06/05 05:00 [entrez]
PST - ppublish
SO  - Yao Xue Xue Bao. 2003 Feb;38(2):133-7.