PMID- 12780476
OWN - NLM
STAT- MEDLINE
DCOM- 20031209
LR  - 20170214
IS  - 0004-8674 (Print)
IS  - 0004-8674 (Linking)
VI  - 37
IP  - 3
DP  - 2003 Jun
TI  - Awareness of illness in patients with bipolar I disorder with or without comorbid 
      anxiety disorders.
PG  - 355-61
AB  - BACKGROUND: The present study examined whether specific types of comorbid anxiety 
      disorders, namely panic disorder (PD), social phobia (SP) and 
      obsessive-compulsive disorder (OCD) are differentially associated with course 
      variables and insight into bipolar illness. METHOD: The sample consisted of 151 
      consecutively hospitalized patients with bipolar I disorder. They were assessed 
      in the week prior to discharge using the Structured Clinical Interview for 
      DSM-III-R (SCID-P), the Brief Psychiatric Rating Scale (BPRS), the Global 
      Assessment of Functioning Scale (GAF) and the Hopkins Symptom Checklist 
      (HSCL-90). Level of insight was assessed with the Scale to assess Unawareness of 
      Mental Disorders (SUMD). RESULTS: Of the 151 bipolar subjects, 92 had no PD, SP 
      and OCD comorbidity, 35 had PD and 24 had SP and/or OCD. The three groups 
      differed significantly on the current awareness of illness and treatment response 
      scores and the retrospective awareness of illness and treatment response scores. 
      Post-hoc analyses revealed that, compared with bipolar patients without PD/SD/OCD 
      and those with comorbid PD, patients with comorbid SP and/or OCD had better 
      insight on current awareness of illness, current awareness of treatment response, 
      retrospective awareness of illness and retrospective awareness of treatment 
      response. The regression analysis showed that the presence of no panic type 
      anxiety comorbidity was a predictor of good insight. CONCLUSIONS: These data 
      indicate the value of identifying comorbid anxiety disorders in patients with 
      bipolar illness. The results could be interpreted as evidence of discrete 
      disorders within the bipolar spectrum, one that is characterized by, among other 
      things, SP and/or OCD with good insight, another characterized by PD with poor 
      insight.
FAU - Pini, Stefano
AU  - Pini S
AD  - Department of Psychiatry, Pharmacology, Neurobiology and Bio-technology, 
      University of Pisa, via Roma 67, 56100 Pisa, Italy. s.pini@psico.med.unipi.it
FAU - Dell'Osso, Liliana
AU  - Dell'Osso L
FAU - Amador, Xavier F
AU  - Amador XF
FAU - Mastrocinque, Concettina
AU  - Mastrocinque C
FAU - Saettoni, Marco
AU  - Saettoni M
FAU - Cassano, Giovanni B
AU  - Cassano GB
LA  - eng
PT  - Journal Article
PL  - England
TA  - Aust N Z J Psychiatry
JT  - The Australian and New Zealand journal of psychiatry
JID - 0111052
SB  - IM
MH  - Adult
MH  - Anxiety/*complications/diagnosis
MH  - *Attitude to Health
MH  - *Awareness
MH  - Bipolar Disorder/*complications/diagnosis
MH  - Delusions/complications/diagnosis
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Hallucinations/complications/diagnosis
MH  - Humans
MH  - Male
MH  - Obsessive-Compulsive Disorder/complications
MH  - Panic Disorder/complications/diagnosis
MH  - Phobic Disorders/*complications/diagnosis
MH  - Surveys and Questionnaires
EDAT- 2003/06/05 05:00
MHDA- 2003/12/10 05:00
CRDT- 2003/06/05 05:00
PHST- 2003/06/05 05:00 [pubmed]
PHST- 2003/12/10 05:00 [medline]
PHST- 2003/06/05 05:00 [entrez]
AID - 1188 [pii]
AID - 10.1046/j.1440-1614.2003.01188.x [doi]
PST - ppublish
SO  - Aust N Z J Psychiatry. 2003 Jun;37(3):355-61. doi: 
      10.1046/j.1440-1614.2003.01188.x.