PMID- 12781135
OWN - NLM
STAT- MEDLINE
DCOM- 20040305
LR  - 20231120
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 13
IP  - 11
DP  - 2003 May 27
TI  - A role of Dishevelled in relocating Axin to the plasma membrane during wingless 
      signaling.
PG  - 960-6
AB  - Wnt signaling causes changes in gene transcription that are pivotal for normal 
      and malignant development. A key effector of the canonical Wnt pathway is 
      beta-catenin, or Drosophila Armadillo. In the absence of Wnt ligand, beta-catenin 
      is phosphorylated by the Axin complex, which earmarks it for rapid degradation by 
      the ubiquitin system. Axin acts as a scaffold in this complex, to assemble 
      beta-catenin substrate and kinases (casein kinase I [CKI] and glycogen synthase 
      kinase 3 beta [GSK3]). The Adenomatous polyposis coli (APC) tumor suppressor also 
      binds to the Axin complex, thereby promoting the degradation of beta-catenin. In 
      Wnt signaling, this complex is inhibited; as a consequence, beta-catenin 
      accumulates and binds to TCF proteins to stimulate the transcription of Wnt 
      target genes. Wnt-induced inhibition of the Axin complex depends on Dishevelled 
      (Dsh), a cytoplasmic protein that can bind to Axin, but the mechanism of this 
      inhibition is not understood. Here, we show that Wingless signaling causes a 
      striking relocation of Drosophila Axin from the cytoplasm to the plasma membrane. 
      This relocation depends on Dsh. It may permit the subsequent inactivation of the 
      Axin complex by Wingless signaling.
FAU - Cliffe, Adam
AU  - Cliffe A
AD  - MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United 
      Kingdom.
FAU - Hamada, Fumihiko
AU  - Hamada F
FAU - Bienz, Mariann
AU  - Bienz M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Axin Protein)
RN  - 0 (Axn protein, Drosophila)
RN  - 0 (Carrier Proteins)
RN  - 0 (Dishevelled Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Luminescent Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Wnt1 Protein)
RN  - 0 (dsh protein, Drosophila)
RN  - 0 (wg protein, Drosophila)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Axin Protein
MH  - Blotting, Western
MH  - Carrier Proteins/*metabolism
MH  - Cell Membrane/metabolism
MH  - Dishevelled Proteins
MH  - Drosophila/genetics
MH  - Drosophila Proteins/*metabolism
MH  - Fluorescent Antibody Technique
MH  - Green Fluorescent Proteins
MH  - Luminescent Proteins
MH  - Phosphoproteins/*metabolism
MH  - Proto-Oncogene Proteins/*metabolism
MH  - *Signal Transduction
MH  - Wnt1 Protein
EDAT- 2003/06/05 05:00
MHDA- 2004/03/06 05:00
CRDT- 2003/06/05 05:00
PHST- 2003/06/05 05:00 [pubmed]
PHST- 2004/03/06 05:00 [medline]
PHST- 2003/06/05 05:00 [entrez]
AID - S0960-9822(03)00370-1 [pii]
AID - 10.1016/s0960-9822(03)00370-1 [doi]
PST - ppublish
SO  - Curr Biol. 2003 May 27;13(11):960-6. doi: 10.1016/s0960-9822(03)00370-1.