PMID- 12782227
OWN - NLM
STAT- MEDLINE
DCOM- 20040116
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 78
IP  - 4-5
DP  - 2003 Apr
TI  - Forebrain sites of NPY action on estrous behavior in Syrian hamsters.
PG  - 711-6
AB  - Food deprivation and similar metabolic challenges inhibit estrous behavior in 
      female Syrian hamsters. The relevant metabolic cues appear to be detected in the 
      hindbrain, and this information is then relayed synaptically to the forebrain 
      circuits controlling estrous behavior. Neuropeptide Y (NPY) may be one of the 
      neuropeptides/neurotransmitters serving this function. Infusion of NPY or the 
      Y2/Y5 agonist, peptide YY3-36 (PYY3-36), into the lateral ventricles rapidly 
      inhibits estrous behavior in ovariectomized, steroid-primed hamsters. This 
      experiment sought to determine the neural loci where NPY acts to inhibit estrous 
      behavior. Steroid-primed animals received infusions of artificial cerebrospinal 
      fluid (aCSF) vehicle, 0.024 nmol PYY3-36 and 0.24 nmol PYY3-36 in separate tests 
      30 min prior to testing for sexual receptivity. Infusion of 0.24 nmol, but not 
      0.024 nmol, of PYY3-36 reduced lordosis duration when infused into the 
      paraventricular nucleus of the hypothalamus (PVN), the caudal part of the medial 
      preoptic area (MPO), the anterior hypothalamus (AH) or the lateral ventricles. 
      Placements in the ventromedial hypothalamus (VMH), the arcuate nucleus (ARC) and 
      the fourth ventricle were generally without effect. These data suggest that 
      increased endogenous release of NPY into the caudal MPO-AH-PVN continuum during 
      food deprivation could contribute to the observed inhibition of sexual 
      receptivity. The possible contributions of other neuropeptides and neural 
      estrogen receptors to this action of NPY are discussed.
FAU - Keene, Alex C
AU  - Keene AC
AD  - Center for Neuroendocrine Studies, University of Massachusetts, 135 Hicks Way, 
      Amherst, MA 01003, USA.
FAU - Jones, Juli E
AU  - Jones JE
FAU - Wade, George N
AU  - Wade GN
FAU - Corp, Eric S
AU  - Corp ES
LA  - eng
GR  - DK 55829-03/DK/NIDDK NIH HHS/United States
GR  - MH 00312-20/MH/NIMH NIH HHS/United States
GR  - MH 20051-01/MH/NIMH NIH HHS/United States
GR  - NS 10873-30/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Neuropeptide Y)
SB  - IM
MH  - Animals
MH  - Cricetinae
MH  - Estrous Cycle/*physiology
MH  - Female
MH  - Food Deprivation/physiology
MH  - Mesocricetus
MH  - Neuropeptide Y/*physiology
MH  - Ovariectomy
MH  - Posture
MH  - Preoptic Area/physiology
MH  - Prosencephalon/*physiology
MH  - Sexual Behavior, Animal/drug effects
EDAT- 2003/06/05 05:00
MHDA- 2004/01/17 05:00
CRDT- 2003/06/05 05:00
PHST- 2003/06/05 05:00 [pubmed]
PHST- 2004/01/17 05:00 [medline]
PHST- 2003/06/05 05:00 [entrez]
AID - S0031938403000489 [pii]
AID - 10.1016/s0031-9384(03)00048-9 [doi]
PST - ppublish
SO  - Physiol Behav. 2003 Apr;78(4-5):711-6. doi: 10.1016/s0031-9384(03)00048-9.