PMID- 12784918
OWN - NLM
STAT- MEDLINE
DCOM- 20030908
LR  - 20191107
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 25
IP  - 2
DP  - 2003 May
TI  - Inhibition of immunologic and nonimmunologic stimulation-mediated anaphylactic 
      reactions by the aqueous extract of Mentha arvensis.
PG  - 273-83
AB  - The effect of aqueous extract of Mentha arvensis L. var. piperascens Malinv. 
      (Labiatae) (MAAE) on immunologic and nonimmunologic stimulation-mediated 
      anaphylactic reactions was studied. Nonimmunologic anaphylactic reaction was 
      induced by compound 48/80 injection. MAAE (0.005 to 0.5 g/kg) inhibited systemic 
      anaphylactic reaction induced by compound 48/80. Immunologic anaphylactic 
      reaction was generated by sensitizing the skin with anti-dinitrophenyl (DNP) IgE 
      followed 48 h later with an injection of antigen. MAAE (0.001 to 1 g/kg) 
      dose-dependently inhibited passive cutaneous anaphylaxis (PCA) when 
      intraperitoneally, intraveneously and orally administered. MAAE (0.001 to 1 
      mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast 
      cells (RPMC) activated by compound 48/80 or anti-DNP IgE. Moreover, MAAE (0.1 
      mg/ml) had a significant inhibitory effect on anti-DNP IgE-mediated tumor 
      necrosis factor-alpha (TNF-alpha) production. These results indicate that MAAE 
      inhibits immunologic and nonimmunologic stimulation-mediated anaphylactic 
      reactions and TNF-alpha production from RPMC.
FAU - Shin, Tae-Yong
AU  - Shin TY
AD  - College of Pharmacy, Woosuk University, Jeonju, Jeonbuk, South Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Dinitrophenols)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Administration, Oral
MH  - Anaphylaxis/chemically induced/drug therapy/*immunology
MH  - Animals
MH  - Dinitrophenols/immunology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Histamine Release/drug effects/*immunology
MH  - Immunoglobulin E/immunology
MH  - Injections, Intraperitoneal
MH  - Injections, Intravenous
MH  - *Mast Cells/drug effects/immunology/metabolism
MH  - *Mentha
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Passive Cutaneous Anaphylaxis/*drug effects/immunology
MH  - Plant Extracts/administration & dosage/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/immunology
MH  - p-Methoxy-N-methylphenethylamine/toxicity
EDAT- 2003/06/06 05:00
MHDA- 2003/09/10 05:00
CRDT- 2003/06/06 05:00
PHST- 2003/06/06 05:00 [pubmed]
PHST- 2003/09/10 05:00 [medline]
PHST- 2003/06/06 05:00 [entrez]
AID - 10.1081/iph-120020475 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2003 May;25(2):273-83. doi: 10.1081/iph-120020475.