PMID- 12787307
OWN - NLM
STAT- MEDLINE
DCOM- 20040316
LR  - 20190916
IS  - 1320-5463 (Print)
IS  - 1320-5463 (Linking)
VI  - 53
IP  - 6
DP  - 2003 Jun
TI  - Phenotypic analysis of peripheral T/NK cell lymphoma: study of 408 Japanese cases 
      with special reference to their anatomical sites.
PG  - 333-44
AB  - The World Health Organization (WHO) classification of malignant lymphoma 
      presented a list of disease entities well defined by clinical, immunological and 
      genetic features. Therefore, the current diagnosis of peripheral T/NK-cell 
      lymphomas (PTNKLs) essentially requires the inclusion of anatomical sites of 
      disease and phenotypical features. We analyzed 408 Japanese cases of PTNKLs in 
      order to clarify the relationship between anatomical sites of disease and 
      phenotypical features and to translate the functional subsets of T and NK cells 
      into their diagnoses for further understanding lymphomatic biology. The T/NK-cell 
      lymphoma entities were allocated into three categories: (i) cytotoxic memory 
      T-cell and/or NK-cell lymphoma (n = 151) consisting of extranodal NK/T-cell 
      tumors other than mycosis fungoides (MF); (ii) non-cytotoxic memory T-cell 
      lymphoma (n = 142) consisting of nodal and cutaneous tumors such as 
      angioimmunoblastic T-cell lymphoma, adult T-cell lymphoma/leukemia and MF; and 
      (iii) anaplastic lymphoma kinase positive anaplastic large cell lymphoma (n = 
      110) that has unique features and might be regarded as cytotoxic 'naive' T-cell 
      lymphoma. Overall, these three categories were significantly correlated with age 
      of onset, anatomical sites, the level of expression of cytotoxic molecules and 
      CD45RO, and association with Epstein-Barr virus. This concept might provide a new 
      insight enabling further understanding of the interrelationships among WHO 
      T/NK-cell disease entities.
FAU - Ichimura, Koichi
AU  - Ichimura K
AD  - Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, 
      Japan.
FAU - Kagami, Yoshitoyo
AU  - Kagami Y
FAU - Suzuki, Ritsuro
AU  - Suzuki R
FAU - Kojima, Masaru
AU  - Kojima M
FAU - Yoshino, Tadashi
AU  - Yoshino T
FAU - Ohshima, Koichi
AU  - Ohshima K
FAU - Koike, Koichi
AU  - Koike K
FAU - Kondo, Eisei
AU  - Kondo E
FAU - Taji, Hirofumi
AU  - Taji H
FAU - Ogura, Michinori
AU  - Ogura M
FAU - Morishima, Yasuo
AU  - Morishima Y
FAU - Akagi, Tadaatsu
AU  - Akagi T
FAU - Takahashi, Toshitada
AU  - Takahashi T
FAU - Nakamura, Shigeo
AU  - Nakamura S
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Membrane Proteins)
RN  - 0 (Poly(A)-Binding Proteins)
RN  - 0 (Proteins)
RN  - 0 (RNA, Viral)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (T-Cell Intracellular Antigen-1)
RN  - 0 (TIA1 protein, human)
RN  - EC 3.4.21.- (GZMB protein, human)
RN  - EC 3.4.21.- (Granzymes)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/metabolism
MH  - Child
MH  - Child, Preschool
MH  - DNA, Neoplasm/analysis
MH  - Female
MH  - Flow Cytometry
MH  - Granzymes
MH  - Herpesvirus 4, Human/isolation & purification
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunophenotyping
MH  - In Situ Hybridization
MH  - Killer Cells, Natural/*pathology/virology
MH  - Lymphoma, T-Cell, Peripheral/*immunology/*pathology/virology
MH  - Male
MH  - Membrane Proteins/analysis
MH  - Middle Aged
MH  - Poly(A)-Binding Proteins
MH  - *Proteins
MH  - RNA, Viral/analysis
MH  - RNA-Binding Proteins/analysis
MH  - Serine Endopeptidases/analysis
MH  - T-Cell Intracellular Antigen-1
MH  - *World Health Organization
EDAT- 2003/06/06 05:00
MHDA- 2004/03/17 05:00
CRDT- 2003/06/06 05:00
PHST- 2003/06/06 05:00 [pubmed]
PHST- 2004/03/17 05:00 [medline]
PHST- 2003/06/06 05:00 [entrez]
AID - 1479 [pii]
AID - 10.1046/j.1440-1827.2003.01479.x [doi]
PST - ppublish
SO  - Pathol Int. 2003 Jun;53(6):333-44. doi: 10.1046/j.1440-1827.2003.01479.x.