PMID- 12787315
OWN - NLM
STAT- MEDLINE
DCOM- 20040316
LR  - 20190916
IS  - 1320-5463 (Print)
IS  - 1320-5463 (Linking)
VI  - 53
IP  - 6
DP  - 2003 Jun
TI  - Intra-epithelial neuroendocrine carcinoma of the nasal cavity.
PG  - 396-400
AB  - We describe a distinctive neuroendocrine carcinoma (NEC) that proliferated 
      intra-epithelially. The tumor was 35 mm in diameter and arose from the right 
      superior turbinate of a 46-year-old woman. Histologically, the tumor exhibited 
      papillary growth and the tumor cells were localized in the thickened mucosal 
      epithelium. The tumor cells had round to oval and vesicular or hyperchromatic 
      nuclei, and cohered without any specific structure such as a fibrillary 
      background, rosette or glandular structure. No stromal invasion by the tumor was 
      observed. Immunohistochemically, the tumor cells were positive for 
      neuron-specific enolase focally. In addition, many tumor cells expressed 
      cytokeratin (AE1/AE3 and CAM 5.2), mostly with characteristic perinuclear 
      dot-like patterns. Electron microscopy revealed focal but well-eveloped 
      cytoplasmic processes containing arrays of microtubules and a few dense core 
      granules. The tumor was considered to be a poorly differentiated neuroendocrine 
      carcinomas (NEC) that exhibited exceptional intra-epithelial proliferation. The 
      tumor completely disappeared after the stereotactic radiosurgery and has not 
      recurred for 40 months. It might be difficult to distinguish a poorly 
      differentiated NEC in the sinonasal region from other neuroectodermal tumors, 
      including olfactory neuroblastoma, but the differential diagnosis is important 
      because each tumor has different clinicopathological characteristics.
FAU - Watanabe, Kazuo
AU  - Watanabe K
AD  - Pathology Division, Fukushima Medical University School of Medicine Hospital, 
      Fukushima, Japan. w-kazuo@fmu.ac.jp
FAU - Ogura, Go
AU  - Ogura G
FAU - Suzuki, Toshimitsu
AU  - Suzuki T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Biomarkers, Tumor)
RN  - 68238-35-7 (Keratins)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Biomarkers, Tumor
MH  - Carcinoma, Neuroendocrine/metabolism/*pathology/surgery
MH  - Cytoplasmic Structures/ultrastructure
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Keratins/metabolism
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Nasal Cavity/*pathology
MH  - Nose Neoplasms/metabolism/*pathology/surgery
MH  - Phosphopyruvate Hydratase/metabolism
MH  - Radiosurgery
MH  - Treatment Outcome
EDAT- 2003/06/06 05:00
MHDA- 2004/03/17 05:00
CRDT- 2003/06/06 05:00
PHST- 2003/06/06 05:00 [pubmed]
PHST- 2004/03/17 05:00 [medline]
PHST- 2003/06/06 05:00 [entrez]
AID - 1487 [pii]
AID - 10.1046/j.1440-1827.2003.01487.x [doi]
PST - ppublish
SO  - Pathol Int. 2003 Jun;53(6):396-400. doi: 10.1046/j.1440-1827.2003.01487.x.