PMID- 12788125
OWN - NLM
STAT- MEDLINE
DCOM- 20030617
LR  - 20190627
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 135
IP  - 6
DP  - 2003 Jun
TI  - Relationship between human leukocyte antigen status and proliferative diabetic 
      retinopathy in patients with younger-onset type 1 diabetes mellitus.
PG  - 844-8
AB  - PURPOSE: To investigate the relationship between human leukocyte antigen (HLA) 
      status and proliferative diabetic retinopathy (PDR) to assess the genetic basis 
      of PDR in younger type 1 diabetic patients. DESIGN: Retrospective, nonrandomized, 
      comparative trial. METHOD: Patients who were diagnosed with type 1 diabetes under 
      30 years of age (range, 13-28) and had a disease duration of more than 10 years 
      were studied. The patients were divided into two groups: 30 patients who had 
      undergone vitreous surgery younger than 40 years old (the PDR group) and 50 
      patients without retinopathy (the non-DR group). The duration of diabetes and the 
      level of glycemic control were matched between the two groups. The control group 
      consisted of 50 healthy patients. HLA-A, -B, -C, -DR, and -DQ typing of blood 
      samples was done using the standard microcytotoxicity method. RESULTS: The 
      frequency of HLA-B62, Cw4, and DQ4 was significantly higher in the PDR group than 
      in the non-DR group (P =.0020, P =.048, and P =.0026, respectively). The 
      Cw4-DR4-DQ4 haplotype frequency was significantly higher in the PDR group than in 
      the control group and the non-DR group (P =.0059). CONCLUSIONS: Our results 
      suggests that HLA-B62, Cw4, and DQ4 may be useful for predicting the prognosis of 
      retinopathy in patients with younger-onset type 1 diabetes.
FAU - Mimura, Tatsuya
AU  - Mimura T
AD  - Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, 
      Japan. mimura@mbg.shere.ne.jp
FAU - Funatsu, Hideharu
AU  - Funatsu H
FAU - Uchigata, Yasuko
AU  - Uchigata Y
FAU - Kitano, Shigehiko
AU  - Kitano S
FAU - Noma, Hidetaka
AU  - Noma H
FAU - Shimizu, Erika
AU  - Shimizu E
FAU - Konno, Yasuhiro
AU  - Konno Y
FAU - Amano, Shiro
AU  - Amano S
FAU - Araie, Makoto
AU  - Araie M
FAU - Yoshino, Osamu
AU  - Yoshino O
FAU - Iwamoto, Yasuhiko
AU  - Iwamoto Y
FAU - Hori, Sadao
AU  - Hori S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Blood Glucose)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Cytotoxicity Tests, Immunologic
MH  - Diabetes Mellitus, Type 1/*genetics/physiopathology
MH  - Diabetic Retinopathy/*genetics/physiopathology
MH  - Female
MH  - Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Retrospective Studies
EDAT- 2003/06/06 05:00
MHDA- 2003/06/18 05:00
CRDT- 2003/06/06 05:00
PHST- 2003/06/06 05:00 [pubmed]
PHST- 2003/06/18 05:00 [medline]
PHST- 2003/06/06 05:00 [entrez]
AID - S0002939402022912 [pii]
AID - 10.1016/s0002-9394(02)02291-2 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2003 Jun;135(6):844-8. doi: 10.1016/s0002-9394(02)02291-2.