PMID- 12790335
OWN - NLM
STAT- MEDLINE
DCOM- 20030918
LR  - 20190906
IS  - 0080-0015 (Print)
IS  - 0080-0015 (Linking)
VI  - 162
DP  - 2003
TI  - Molecular whole-body cancer staging using positron emission tomography: 
      consequences for therapeutic management and metabolic radiation treatment 
      planning.
PG  - 195-202
AB  - A prospective analysis was performed in 124 non-small cell lung cancer patients 
      to determine the role of F-18 fluorodeoxyglucose (FDG)-positron emission 
      tomography (PET) for molecular (metabolic) staging (n=63), therapy monitoring 
      after induction-chemotherapy (n=34), and conformal radiation treatment planning 
      (n=27). Staging by FDG-PET was significantly more accurate than CT (p<0.001) and 
      changed therapeutic management in 52% of all patients. After 
      induction-chemotherapy, patients with complete metabolic remission histologically 
      did not show vital tumor cells in contrast to patients with metabolic partial 
      remission or progressive disease. Metabolic radiation treatment planning by PET 
      led to smaller planning target volumes (PTVs) for radiation therapy (between 3% 
      and 21% in 25/27 patients), resulting in a reduction of dose exposure to healthy 
      tissue. In two patients, PET-PTV was larger than CT-based PTV, since PET detected 
      lymph node metastases smaller than 1 cm. FDG-PET provides clinically important 
      information; changes therapeutic management, can predict noninvasively 
      effectiveness of chemotherapy, and may lead to better tumor control with less 
      radiation-induced toxicity.
FAU - Schmucking, Michael
AU  - Schmucking M
AD  - Klinik fur Nuklearmedizin, Zentralklinik Bad Berka, 99437 Bad Berka, Germany.
FAU - Baum, Richard P
AU  - Baum RP
FAU - Griesinger, Frank
AU  - Griesinger F
FAU - Presselt, Norbert
AU  - Presselt N
FAU - Bonnet, Reiner
AU  - Bonnet R
FAU - Przetak, Christian
AU  - Przetak C
FAU - Niesen, Andreas
AU  - Niesen A
FAU - Leonhardi, Jochen
AU  - Leonhardi J
FAU - Lopatta, Eric C
AU  - Lopatta EC
FAU - Herse, Bernhard
AU  - Herse B
FAU - Wendt, Thomas G
AU  - Wendt TG
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Recent Results Cancer Res
JT  - Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans 
      les recherches sur le cancer
JID - 0044671
SB  - IM
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Neoplasm Staging/methods
MH  - Neoplasms/*radiotherapy
MH  - Prospective Studies
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Conformal/methods
MH  - Tomography, Emission-Computed/*methods
MH  - Tomography, X-Ray Computed
EDAT- 2003/06/07 05:00
MHDA- 2003/09/19 05:00
CRDT- 2003/06/07 05:00
PHST- 2003/06/07 05:00 [pubmed]
PHST- 2003/09/19 05:00 [medline]
PHST- 2003/06/07 05:00 [entrez]
AID - 10.1007/978-3-642-59349-9_19 [doi]
PST - ppublish
SO  - Recent Results Cancer Res. 2003;162:195-202. doi: 10.1007/978-3-642-59349-9_19.