PMID- 12791299
OWN - NLM
STAT- MEDLINE
DCOM- 20040218
LR  - 20191025
IS  - 0962-8924 (Print)
IS  - 0962-8924 (Linking)
VI  - 13
IP  - 6
DP  - 2003 Jun
TI  - How to make tubes: signaling by the Met receptor tyrosine kinase.
PG  - 328-35
AB  - Hepatocyte growth factor/scatter factor (HGF/SF), acting through the receptor 
      tyrosine kinase Met, stimulates cells derived from a variety of different organs 
      to form elongated hollow tubules when grown in three-dimensional gels. In vivo 
      data also indicate a role for HGF/SF and Met in tubule formation during liver and 
      kidney regeneration and mammary gland formation. Activation of Met results in the 
      recruitment of a myriad of signal transducers that regulate dissociation of 
      adherens junctions and the stimulation of cellular motility, survival, 
      proliferation and morphogenesis during tubule formation. Among these many signal 
      transducers, the Gab1 adaptor protein and its effector, the SHP2 tyrosine 
      phosphatase, have been found to be crucial for tubulogenesis and for the 
      sustained stimulation of the ERK/MAP kinase pathway. Here, we discuss the 
      contribution of these and other signaling pathways and the role of HGF/SF and Met 
      in the formation of epithelial cell tubules both in vitro in 
      branching-morphogenesis assays and in vivo during organogenesis.
FAU - Rosario, Marta
AU  - Rosario M
AD  - Max-Delbruck-Center for Molecular Medicine, Robert-Rossle-Strasse 10, 13125 
      Berlin, Germany.
FAU - Birchmeier, Walter
AU  - Birchmeier W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Trends Cell Biol
JT  - Trends in cell biology
JID - 9200566
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Microtubules/*physiology
MH  - Protein-Tyrosine Kinases/physiology
MH  - Receptor Protein-Tyrosine Kinases/*physiology
MH  - Signal Transduction/*physiology
RF  - 83
EDAT- 2003/06/07 05:00
MHDA- 2004/02/19 05:00
CRDT- 2003/06/07 05:00
PHST- 2003/06/07 05:00 [pubmed]
PHST- 2004/02/19 05:00 [medline]
PHST- 2003/06/07 05:00 [entrez]
AID - S0962892403001041 [pii]
AID - 10.1016/s0962-8924(03)00104-1 [doi]
PST - ppublish
SO  - Trends Cell Biol. 2003 Jun;13(6):328-35. doi: 10.1016/s0962-8924(03)00104-1.