PMID- 12791336
OWN - NLM
STAT- MEDLINE
DCOM- 20031205
LR  - 20191107
IS  - 1525-5050 (Print)
IS  - 1525-5050 (Linking)
VI  - 4
IP  - 3
DP  - 2003 Jun
TI  - Clinical and EEG findings in six patients with altered mental status receiving 
      tiagabine therapy.
PG  - 326-37
AB  - Tiagabine (TGB), a novel GABA reuptake inhibitor antiepileptic drug, has been 
      reported to induce nonconvulsive status epilepticus (NCSE) in patients with 
      generalized or partial onset seizures. We describe six patients with refractory 
      partial epilepsy treated with add-on TGB. They developed acute intermittent or 
      progressive chronic confusion associated with diffuse slowing of the 
      electroencephalogram (EEG), shortly after an increase in dose of TGB. This 
      remitted in each situation after reduction of the daily dose. The possibility of 
      nonconvulsive status epilepticus or toxic encephalopathy is discussed.
FAU - de Borchgrave, V
AU  - de Borchgrave V
AD  - Centre neurologique William Lennox, Universite Catholique de Louvain, Allee de 
      Clerlande, 6, B-1340 Ottignies-LLN, Belgium.
FAU - Lienard, F
AU  - Lienard F
FAU - Willemart, Th
AU  - Willemart T
FAU - van Rijckevorsel, K
AU  - van Rijckevorsel K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
RN  - 0 (Anticonvulsants)
RN  - 0 (Nipecotic Acids)
RN  - Z80I64HMNP (Tiagabine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anticonvulsants/*therapeutic use
MH  - Chronic Disease
MH  - Consciousness Disorders/*diagnosis/*etiology
MH  - Electroencephalography
MH  - *Epilepsies, Partial/complications/diagnosis/drug therapy
MH  - *Epilepsy, Generalized/complications/diagnosis/drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Nipecotic Acids/*therapeutic use
MH  - Severity of Illness Index
MH  - Tiagabine
RF  - 24
EDAT- 2003/06/07 05:00
MHDA- 2003/12/06 05:00
CRDT- 2003/06/07 05:00
PHST- 2003/06/07 05:00 [pubmed]
PHST- 2003/12/06 05:00 [medline]
PHST- 2003/06/07 05:00 [entrez]
AID - S1525505003001070 [pii]
AID - 10.1016/s1525-5050(03)00107-0 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2003 Jun;4(3):326-37. doi: 10.1016/s1525-5050(03)00107-0.