PMID- 12792524
OWN - NLM
STAT- MEDLINE
DCOM- 20030619
LR  - 20041117
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 75
IP  - 9
DP  - 2003 May 15
TI  - Humoral immune reactivity against human leukocyte antigen (HLA)-DQ graft 
      molecules in the early posttransplantation period.
PG  - 1601-3
AB  - Humoral graft-specific alloreactivity was investigated in 110 renal transplant 
      (RTx) recipients (group A) starting immediately postTx and in 32 RTx candidates 
      sensitized against a failed graft (group B) using an enzyme-linked immunosorbent 
      assay (ELISA) assay. All patients received a human leukocyte antigen (HLA) class 
      I and II incompatible graft. Donor-specific (DS) antibodies were detected in 11 
      of 110 (90.9%) group-A patients, predominately during the first 6 months postTx. 
      In all 11 cases, only HLA class II antibodies were detected. Ten of 11 
      antibody-positive patients received an HLA-DR, HLA-DQ incompatible graft, and all 
      patients had HLA-DQ DS antibodies, either alone (n=8) or with HLA-DR antibodies 
      (n=2). HLA-DQ antibodies were also detected in 80.9% of group-B patients. The 
      presence of HLA-DQ DS antibodies in the early postTx period does not identify 
      patients with rejection or deterioration of graft function. Whether these 
      patients are at high risk for graft loss remains to be clarified.
FAU - Iniotaki-Theodoraki, Aliki G
AU  - Iniotaki-Theodoraki AG
AD  - National Tissue Typing Center, General State Hospital of Athens, Greece. 
      gtheo@bigfoot.com
FAU - Boletis, John N
AU  - Boletis JN
FAU - Trigas, George Ch
AU  - Trigas GCh
FAU - Kalogeropoulou, Helen G
AU  - Kalogeropoulou HG
FAU - Kostakis, Alkiviadis G
AU  - Kostakis AG
FAU - Stavropoulos-Giokas, Catherine G
AU  - Stavropoulos-Giokas CG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Graft Rejection
MH  - HLA-DQ Antigens/*immunology
MH  - Humans
MH  - Isoantibodies/*blood
MH  - Kidney Transplantation/*immunology
MH  - Tissue Donors
EDAT- 2003/06/07 05:00
MHDA- 2003/06/20 05:00
CRDT- 2003/06/07 05:00
PHST- 2003/06/07 05:00 [pubmed]
PHST- 2003/06/20 05:00 [medline]
PHST- 2003/06/07 05:00 [entrez]
AID - 10.1097/01.TP.0000061611.51612.09 [doi]
PST - ppublish
SO  - Transplantation. 2003 May 15;75(9):1601-3. doi: 
      10.1097/01.TP.0000061611.51612.09.