PMID- 12792739
OWN - NLM
STAT- MEDLINE
DCOM- 20040206
LR  - 20061115
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 10
IP  - 4
DP  - 2003 Jul-Aug
TI  - Overexpression of the thrombospondin 2 (TSP2) gene modulated by the matrix 
      metalloproteinase family expression and production in human colon carcinoma cell 
      line.
PG  - 881-4
AB  - Thrombospondin 2 (TSP2) is an extracellular matrix glycoprotein involved in tumor 
      progression and angiogenesis. We evaluated whether overexpression of the TSP2 
      gene show an alteration of various genes by cDNA arrays in the colon carcinoma 
      cell line SW480. The transformants with the human TSP2 gene overexpression showed 
      a down-regulation of matrix metalloproteinase 2 (MMP2) and MMP9 in comparison to 
      those with vector-control. Protein production of MMP2 and MMP9 decreased in the 
      transformants overexpressing the TSP2 gene. Conversely, the SW480 transformants 
      showed up-regulation of MMP12 and MMP17. These results suggested that the TSP2 
      gene is a multifunctional modulator of remodeling tissue in which matrix 
      degradation is required.
FAU - Kamochi, Junichiro
AU  - Kamochi J
AD  - Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, 
      Kanagawa 259-1143, Japan.
FAU - Tokunaga, Tetsuji
AU  - Tokunaga T
FAU - Tomii, Yasushi
AU  - Tomii Y
FAU - Abe, Yoshiyuki
AU  - Abe Y
FAU - Hatanaka, Hiroyuki
AU  - Hatanaka H
FAU - Kijima, Hiroshi
AU  - Kijima H
FAU - Yamazaki, Hitoshi
AU  - Yamazaki H
FAU - Watanabe, Norihito
AU  - Watanabe N
FAU - Matsuzaki, Shohei
AU  - Matsuzaki S
FAU - Ueyama, Yoshito
AU  - Ueyama Y
FAU - Nakamura, Masato
AU  - Nakamura M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Thrombospondins)
RN  - 0 (thrombospondin 2)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Blotting, Northern
MH  - Cell Adhesion Molecules/physiology
MH  - Colonic Neoplasms/*metabolism
MH  - Down-Regulation
MH  - Gene Expression/physiology
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Enzymologic/*physiology
MH  - Humans
MH  - Matrix Metalloproteinases/*genetics/metabolism
MH  - Oligonucleotide Array Sequence Analysis
MH  - Thrombospondins/*genetics
MH  - Tumor Cells, Cultured
EDAT- 2003/06/07 05:00
MHDA- 2004/02/10 05:00
CRDT- 2003/06/07 05:00
PHST- 2003/06/07 05:00 [pubmed]
PHST- 2004/02/10 05:00 [medline]
PHST- 2003/06/07 05:00 [entrez]
PST - ppublish
SO  - Oncol Rep. 2003 Jul-Aug;10(4):881-4.