PMID- 12795639
OWN - NLM
STAT- MEDLINE
DCOM- 20030917
LR  - 20190827
IS  - 0014-2972 (Print)
IS  - 0014-2972 (Linking)
VI  - 33
IP  - 6
DP  - 2003 Jun
TI  - Prognostic significance of soluble interleukin-2 receptor levels in patients with 
      dilated cardiomyopathy.
PG  - 443-8
AB  - BACKGROUND: Activation of T lymphocytes is thought to mediate myocardial 
      dysfunction in dilated cardiomyopathy (CMP), probably through cytotoxic 
      cytokines, but its value as a prognostic factor has not been evaluated. METHODS: 
      For 2 years we prospectively followed 76 patients (65 males, 11 females, age 49 
      +/- 7 years) with CMP and New York Heart Association(NYHA) Class II-III heart 
      failure; left ventricular (LV) function was assessed echocardiographically. 
      Thirty-three patients (28 males, five females, age 52 +/- 6 years) with ischaemic 
      heart disease (IHD) and similar NYHA and LV function characteristics were used as 
      controls. Serum sIL-2R levels, peripheral blood lymphocyte proliferation (basal, 
      + concanavalin A) and HLA-DQB1 genotyping was carried out in all patients. 
      RESULTS: The CMP patients had increased sIL-2R levels (1259 +/- 130 pg mL-1) 
      compared with the IHD patients (703 +/- 80 pg mL-1, P < 0.01, only 3 > 800 pg 
      mL-1). In the CMP patients, there was a significant (r = +0.45, P= 0.04) 
      correlation between sIL-2R and the LV end-diastolic diameter but not with the LV 
      ejection fraction or NYHA Class. During the 24-month follow up, 17 of the CMP 
      patients had an adverse clinical course (death, need for cardiac transplantation, 
      or worsening heart failure). Of these, 14 (75%) had elevated (>or= 800 pg mL-1) 
      sIL-2R levels (Group I) compared with only five (6%) with a stable clinical 
      course (Group II). Neither [3H] thymidine incorporation into the peripheral blood 
      lymphocytes nor the excess of HLA-DQB1-30 histidine homozygotes in the Group I 
      patients (38% vs. 17%, P < 0.05) could predict the clinical outcome. CONCLUSION: 
      Increased sIL-2R levels in CMP patients are an independent predictor of a more 
      aggressive clinical course.
FAU - Limas, C J
AU  - Limas CJ
AD  - Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Hasikidis, C
AU  - Hasikidis C
FAU - Iakovou, J
AU  - Iakovou J
FAU - Kroupis, C
AU  - Kroupis C
FAU - Haidaroglou, A
AU  - Haidaroglou A
FAU - Cokkinos, D V
AU  - Cokkinos DV
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
CIN - Eur J Clin Invest. 2003 Nov;33(11):1020; author reply 1021. PMID: 14636309
MH  - Cardiomyopathy, Dilated/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Receptors, Interleukin-2/*blood
MH  - Severity of Illness Index
MH  - Solubility
MH  - T-Lymphocytes
EDAT- 2003/06/11 05:00
MHDA- 2003/09/18 05:00
CRDT- 2003/06/11 05:00
PHST- 2003/06/11 05:00 [pubmed]
PHST- 2003/09/18 05:00 [medline]
PHST- 2003/06/11 05:00 [entrez]
AID - 1111 [pii]
AID - 10.1046/j.1365-2362.2003.01111.x [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2003 Jun;33(6):443-8. doi: 10.1046/j.1365-2362.2003.01111.x.