PMID- 12796784
OWN - NLM
STAT- MEDLINE
DCOM- 20030814
LR  - 20190227
IS  - 1097-6256 (Print)
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Linking)
VI  - 6
IP  - 7
DP  - 2003 Jul
TI  - Brain-derived neurotrophic factor regulates energy balance downstream of 
      melanocortin-4 receptor.
PG  - 736-42
AB  - The melanocortin-4 receptor (MC4R) is critically involved in regulating energy 
      balance, and obesity has been observed in mice with mutations in the gene for 
      brain-derived neurotrophic factor (BDNF). Here we report that BDNF is expressed 
      at high levels in the ventromedial hypothalamus (VMH) where its expression is 
      regulated by nutritional state and by MC4R signaling. In addition, similar to 
      MC4R mutants, mouse mutants that expresses the BDNF receptor TrkB at a quarter of 
      the normal amount showed hyperphagia and excessive weight gain on higher-fat 
      diets. Furthermore, BDNF infusion into the brain suppressed the hyperphagia and 
      excessive weight gain observed on higher-fat diets in mice with deficient MC4R 
      signaling. These results show that MC4R signaling controls BDNF expression in the 
      VMH and support the hypothesis that BDNF is an important effector through which 
      MC4R signaling controls energy balance.
FAU - Xu, Baoji
AU  - Xu B
AD  - Howard Hughes Medical Institute, University of California, San Francisco, 
      California 94143, USA. bx3@georgetown.edu
FAU - Goulding, Evan H
AU  - Goulding EH
FAU - Zang, Keling
AU  - Zang K
FAU - Cepoi, David
AU  - Cepoi D
FAU - Cone, Roger D
AU  - Cone RD
FAU - Jones, Kevin R
AU  - Jones KR
FAU - Tecott, Laurence H
AU  - Tecott LH
FAU - Reichardt, Louis F
AU  - Reichardt LF
LA  - eng
GR  - P01 NS016033/NS/NINDS NIH HHS/United States
GR  - P01 NS016033-21/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Melanins)
RN  - 0 (Receptor, Melanocortin, Type 4)
RN  - 0 (Receptors, Corticotropin)
RN  - 581-05-5 (alpha-MSH)
SB  - IM
CIN - Nat Neurosci. 2003 Jul;6(7):655-6. PMID: 12830151
MH  - Animals
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Circadian Rhythm/physiology
MH  - Energy Metabolism/*physiology
MH  - Feeding Behavior
MH  - Female
MH  - Hypothalamus, Middle/*metabolism
MH  - Male
MH  - Melanins/genetics/metabolism
MH  - Mice
MH  - Receptor, Melanocortin, Type 4/*metabolism
MH  - Receptors, Corticotropin/genetics/*physiology
MH  - alpha-MSH/administration & dosage/*analogs & derivatives
PMC - PMC2710100
MID - NIHMS111805
EDAT- 2003/06/11 05:00
MHDA- 2003/08/15 05:00
PMCR- 2009/07/14
CRDT- 2003/06/11 05:00
PHST- 2003/04/24 00:00 [received]
PHST- 2003/05/07 00:00 [accepted]
PHST- 2003/06/11 05:00 [pubmed]
PHST- 2003/08/15 05:00 [medline]
PHST- 2003/06/11 05:00 [entrez]
PHST- 2009/07/14 00:00 [pmc-release]
AID - nn1073 [pii]
AID - 10.1038/nn1073 [doi]
PST - ppublish
SO  - Nat Neurosci. 2003 Jul;6(7):736-42. doi: 10.1038/nn1073.