PMID- 12796797
OWN - NLM
STAT- MEDLINE
DCOM- 20040301
LR  - 20161124
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 31
IP  - 12
DP  - 2003 Jun
TI  - Successful treatment of bcr/abl-positive acute mixed lineage leukemia by 
      unmanipulated bone marrow transplantation from an HLA-haploidentical 
      (3-antigen-mismatched) cousin.
PG  - 1165-8
AB  - We describe a patient with bcr/abl-positive acute mixed lineage leukemia who 
      successfully underwent transplantation in primary induction failure, using 
      unmanipulated bone marrow from a human leukocyte antigen (HLA)-haploidentical 
      cousin. The tumor burden was successfully reduced by the administration of 
      imatinib mesylate (STI571) before transplantation. As graft-versus-host disease 
      (GVHD) prophylaxis, a combination of tacrolimus and a short course of 
      methotrexate, methylprednisolone, and mycophenolate mofetil was used. 
      Hematopoietic reconstitution was rapid, and acute GVHD was limited to the skin 
      (grade I). The patient is still in complete remission past day +400. This 
      successful case suggests that HLA-haploidentical transplantation using 
      unmanipulated marrow from a distantly related relative can be considered for 
      patients in urgent situations who do not have HLA-identical donors.
FAU - Ikegame, K
AU  - Ikegame K
AD  - Department of Molecular Medicine, Osaka University Graduate School of Medicine, 
      Suita city, Osaka, Japan.
FAU - Mukouchi, C
AU  - Mukouchi C
FAU - Kunitomi, A
AU  - Kunitomi A
FAU - Konaka, Y
AU  - Konaka Y
FAU - Kawakami, M
AU  - Kawakami M
FAU - Nishida, S
AU  - Nishida S
FAU - Taniguchi, Y
AU  - Taniguchi Y
FAU - Fujioka, T
AU  - Fujioka T
FAU - Masuda, T
AU  - Masuda T
FAU - Murakami, M
AU  - Murakami M
FAU - Hosen, N
AU  - Hosen N
FAU - Kim, E H
AU  - Kim EH
FAU - Tsuboi, A
AU  - Tsuboi A
FAU - Oji, Y
AU  - Oji Y
FAU - Oka, Y
AU  - Oka Y
FAU - Sugiyama, H
AU  - Sugiyama H
FAU - Kawase, I
AU  - Kawase I
FAU - Ogawa, H
AU  - Ogawa H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Benzamides)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Piperazines)
RN  - 0 (Pyrimidines)
RN  - 8A1O1M485B (Imatinib Mesylate)
RN  - HU9DX48N0T (Mycophenolic Acid)
RN  - WM0HAQ4WNM (Tacrolimus)
RN  - X4W7ZR7023 (Methylprednisolone)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Adult
MH  - Antineoplastic Agents/therapeutic use
MH  - Benzamides
MH  - Family
MH  - Female
MH  - Genes, abl
MH  - Graft vs Host Disease/prevention & control
MH  - HLA Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - Imatinib Mesylate
MH  - Immunosuppressive Agents/administration & dosage
MH  - Leukemia, Biphenotypic, Acute/genetics/immunology/*therapy
MH  - Methotrexate/administration & dosage
MH  - Methylprednisolone/administration & dosage
MH  - Mycophenolic Acid/administration & dosage/*analogs & derivatives
MH  - Pedigree
MH  - Piperazines/therapeutic use
MH  - Pyrimidines/therapeutic use
MH  - Tacrolimus/administration & dosage
MH  - Tissue Donors
MH  - Transplantation, Homologous
EDAT- 2003/06/11 05:00
MHDA- 2004/03/03 05:00
CRDT- 2003/06/11 05:00
PHST- 2003/06/11 05:00 [pubmed]
PHST- 2004/03/03 05:00 [medline]
PHST- 2003/06/11 05:00 [entrez]
AID - 1704064 [pii]
AID - 10.1038/sj.bmt.1704064 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2003 Jun;31(12):1165-8. doi: 10.1038/sj.bmt.1704064.