PMID- 12797447
OWN - NLM
STAT- MEDLINE
DCOM- 20030630
LR  - 20231213
IS  - 0070-217X (Print)
IS  - 0070-217X (Linking)
VI  - 276
DP  - 2003
TI  - The interaction between dendritic cells and herpes simplex virus-1.
PG  - 145-61
AB  - Dendritic cells (DCs) are the most potent antigen-presenting cells, because they 
      are also able to induce native T cells. Thus they are crucial in the induction of 
      antiviral immune responses. Several viral immune escape mechanisms have been 
      described; here we concentrate on the interaction between DCs and herpes simplex 
      virus type 1 (HSV-1). DCs can be infected by HSV-1; however, only immature DCs 
      generate infectious viral particles, whereas mature DCs do not support virus 
      production and only immediate-early and early viral transcripts are generated. To 
      induce potent immune responses DCs must mature. Interestingly, HSV-1 interferes 
      with this maturation process, thus inhibiting antiviral T cell stimulation. 
      Furthermore, HSV-1 strongly interferes with DC-mediated T cell proliferation. A 
      striking finding was the complete degradation of CD83, the best-known marker for 
      mature DC, after HSV-1 infection in lysosomal compartments. This CD83 degradation 
      coincided with a clearly reduced T cell stimulation representing an additional 
      new escape strategy. The functional role and the importance of CD83 are discussed 
      in detail.
FAU - Kobelt, D
AU  - Kobelt D
AD  - Department of Dermatology, University of Erlangen, Hartmannstrasse 14, 91052 
      Erlangen, Germany.
FAU - Lechmann, M
AU  - Lechmann M
FAU - Steinkasserer, A
AU  - Steinkasserer A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Curr Top Microbiol Immunol
JT  - Current topics in microbiology and immunology
JID - 0110513
RN  - 0 (Antigens, CD)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Antigens, CD
MH  - Cellular Senescence
MH  - Dendritic Cells/immunology/metabolism/pathology/*virology
MH  - Herpesvirus 1, Human/immunology/*physiology
MH  - Humans
MH  - Immunoglobulins/*immunology
MH  - Lymphocyte Activation/immunology
MH  - Membrane Glycoproteins/*immunology
MH  - T-Lymphocytes/*immunology
MH  - CD83 Antigen
RF  - 62
EDAT- 2003/06/12 05:00
MHDA- 2003/07/02 05:00
CRDT- 2003/06/12 05:00
PHST- 2003/06/12 05:00 [pubmed]
PHST- 2003/07/02 05:00 [medline]
PHST- 2003/06/12 05:00 [entrez]
AID - 10.1007/978-3-662-06508-2_7 [doi]
PST - ppublish
SO  - Curr Top Microbiol Immunol. 2003;276:145-61. doi: 10.1007/978-3-662-06508-2_7.