PMID- 12797449
OWN - NLM
STAT- MEDLINE
DCOM- 20030630
LR  - 20190901
IS  - 0070-217X (Print)
IS  - 0070-217X (Linking)
VI  - 276
DP  - 2003
TI  - Dendritic cell vaccination and viral infection--animal models.
PG  - 199-214
AB  - Dendritic cells (DCs) play a pivotal role in the initiation and maintenance of 
      immune responses against viruses and other microbial pathogens. Adoptively 
      transferred, in vitro manipulated DCs presenting antigen derived from different 
      viruses have been shown to elicit cytotoxic T cell (CTL) and T helper (Th) cell 
      responses and to induce protective antiviral immunity. Furthermore, DC-based 
      adoptive immunotherapies have the potential to specifically (re)activate 
      antiviral immunity in chronic viral diseases such as HIV or hepatitis virus 
      infections. Cellular dendritic cell vaccines, however, are not suitable for 
      large-scale prophylactic immunization. Strategies for vaccine development should 
      therefore aim at the specific delivery of microbial antigens to DCs in situ. 
      Furthermore, appropriate mobilization and activation of DCs by the vaccine is 
      important for the generation of optimal antimicrobial immune responses. Here, we 
      discuss recent data on induction of antiviral immunity with various 
      DC-vaccination approaches and outline future directions for the development of 
      specific antigen targeting to DCs.
FAU - Ludewig, B
AU  - Ludewig B
AD  - Institute of Experimental Immunology, Department of Pathology, University of 
      Zurich, Schmelzbergstr. 12, 8091 Zurich, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Curr Top Microbiol Immunol
JT  - Current topics in microbiology and immunology
JID - 0110513
RN  - 0 (Antigens, Viral)
SB  - IM
MH  - Animals
MH  - Antigens, Viral/*immunology/physiology
MH  - Dendritic Cells/*immunology/physiology
MH  - Lymphocyte Activation/*immunology
MH  - Models, Animal
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - *Vaccination
RF  - 73
EDAT- 2003/06/12 05:00
MHDA- 2003/07/02 05:00
CRDT- 2003/06/12 05:00
PHST- 2003/06/12 05:00 [pubmed]
PHST- 2003/07/02 05:00 [medline]
PHST- 2003/06/12 05:00 [entrez]
AID - 10.1007/978-3-662-06508-2_9 [doi]
PST - ppublish
SO  - Curr Top Microbiol Immunol. 2003;276:199-214. doi: 10.1007/978-3-662-06508-2_9.