PMID- 12797468
OWN - NLM
STAT- MEDLINE
DCOM- 20031204
LR  - 20190922
IS  - 1071-5762 (Print)
IS  - 1029-2470 (Linking)
VI  - 37
IP  - 5
DP  - 2003 May
TI  - 3,4-Methylenedioxymethamphetamine (MDMA) abuse may cause oxidative stress and 
      potential free radical damage.
PG  - 491-7
AB  - OBJECTIVE: To investigate whether 3,4-methylenedioxymethamphetamine abuse (MDMA 
      abuse) may cause oxidative stress and potential free radical damage in the bodies 
      of MDMA abusers (MA), and to explore the mechanisms by which MDMA abuse may be 
      causing oxidative stress. METHODS: One hundred and twenty MA and 120 healthy 
      volunteers (HV) were enrolled in a random control study design, in which the 
      level of lipoperoxide (LPO) in erythrocytes, and the levels of Vitamin C (VC), 
      Vitamin E (VE) and beta-carotene (beta-CAR) in plasma as well as the activities 
      of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes were determined 
      by spectrophotometric methods. RESULTS: Compared with the average values of the 
      above biochemical parameters in the HV group, the average value of LPO in 
      erythrocytes in the MA group was significantly increased (P < 0.0001), while the 
      average values of VC, VE and beta-CAR in plasma as well as those of SOD and CAT 
      in erythrocytes in the MA group were significantly decreased (P < 0.0001). The 
      analysis of bivariate correlations suggested that with the increase of the MDMA 
      abuse dose and the MDMA abuse duration, the level of LPO in erythrocytes in the 
      MA was increased (P < 0.0001), while the levels of VC, VE and beta-CAR in plasma 
      as well as the activities of SOD and CAT in erythrocytes in the MA were decreased 
      (P < 0.0001). CONCLUSION: The findings in this study suggest that MDMA abuse may 
      cause oxidative stress and potential free radical damage to MA.
FAU - Zhou, Jun F
AU  - Zhou JF
AD  - Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang 
      Road, Hangzhou, 310009, Zhejiang Province, People's Republic of China. 
      hzzjf@hotmail.com
FAU - Chen, Peng
AU  - Chen P
FAU - Zhou, Ye H
AU  - Zhou YH
FAU - Zhang, Liang
AU  - Zhang L
FAU - Chen, Huai H
AU  - Chen HH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Free Radic Res
JT  - Free radical research
JID - 9423872
RN  - 0 (Free Radicals)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 01YAE03M7J (beta Carotene)
RN  - 1406-18-4 (Vitamin E)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amphetamine-Related Disorders/blood/enzymology/metabolism
MH  - Ascorbic Acid/blood
MH  - Case-Control Studies
MH  - Catalase/blood
MH  - Dose-Response Relationship, Drug
MH  - Erythrocytes/drug effects/enzymology/metabolism
MH  - Free Radicals/*blood
MH  - Humans
MH  - Lipid Peroxidation/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/blood
MH  - Oxidative Stress/*drug effects
MH  - Random Allocation
MH  - Spectrophotometry/methods
MH  - Superoxide Dismutase/blood
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Time Factors
MH  - Vitamin E/blood
MH  - beta Carotene/blood
EDAT- 2003/06/12 05:00
MHDA- 2003/12/05 05:00
CRDT- 2003/06/12 05:00
PHST- 2003/06/12 05:00 [pubmed]
PHST- 2003/12/05 05:00 [medline]
PHST- 2003/06/12 05:00 [entrez]
AID - 10.1080/1071576031000076286 [doi]
PST - ppublish
SO  - Free Radic Res. 2003 May;37(5):491-7. doi: 10.1080/1071576031000076286.