PMID- 12797525
OWN - NLM
STAT- MEDLINE
DCOM- 20031010
LR  - 20190922
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 49
IP  - 3
DP  - 2003 Mar
TI  - Natural killer (NK) cell receptors' repertoire in couples with recurrent 
      spontaneous abortions.
PG  - 183-91
AB  - PROBLEM: Natural killer (NK) cell receptors (NKRs) have been suggested to protect 
      trophoblast, but their function at the fetomaternal interface remains unknown. To 
      investigate if the outcome of pregnancy depends on women's NKRs, we studied the 
      NKR repertoire in couples with recurrent spontaneous abortions (RSA). METHODS: 
      Twenty-six childless couples with > or = 2 abortions, characterized by alloimmune 
      abnormalities, and 26 control couples were genotyped for five killer 
      immunoglobulin-like receptors (KIR) and two CD94/NKG receptors, known to have as 
      ligands human leukocyte antigen (HLA) class I molecules with trophoblastic 
      expression: inhibitory 2DL1,2,3 and activating 2DS1,4 KIRs, inhibitory NKG2A and 
      activating NKG2C. Detected repertoires of women and partners were compared 
      between the two groups. RESULTS: Less aborters than controls were found to have 
      all three inhibitory KIRs (30.77% versus 69.23%, P = 0.01), some of them had only 
      one inhibitory KIR (19.23% versus 3.85%, P = 0.08) and most of them were lacking 
      inhibitory KIRs possessed by their husbands (57.69% versus 15.38%, P = 0.001). 
      CONCLUSIONS: Women with alloimmune abortions have a limited inhibiting KIR 
      repertoire and such miscarriages may occur because trophoblastic HLA class I 
      molecules are recognized by decidual NK cells lacking the appropriate inhibitory 
      KIRs.
FAU - Varla-Leftherioti, Marighoula
AU  - Varla-Leftherioti M
AD  - Immunology Department and RSA Clinic, Helena Venizelou Maternity Hospital, 
      Athens, Greece. gr1bmdr@hol.gr
FAU - Spyropoulou-Vlachou, Maria
AU  - Spyropoulou-Vlachou M
FAU - Niokou, Demetra
AU  - Niokou D
FAU - Keramitsoglou, Theodora
AU  - Keramitsoglou T
FAU - Darlamitsou, Areti
AU  - Darlamitsou A
FAU - Tsekoura, Christina
AU  - Tsekoura C
FAU - Papadimitropoulos, Miltiadis
AU  - Papadimitropoulos M
FAU - Lepage, Virginia
AU  - Lepage V
FAU - Balafoutas, Christos
AU  - Balafoutas C
FAU - Stavropoulos-Giokas, Catherine
AU  - Stavropoulos-Giokas C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Antigens, CD)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (KLRC1 protein, human)
RN  - 0 (KLRC2 protein, human)
RN  - 0 (KLRD1 protein, human)
RN  - 0 (Lectins, C-Type)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily C)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily D)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL1)
RN  - 0 (Receptors, Natural Killer Cell)
SB  - IM
MH  - Abortion, Habitual/blood/genetics/*immunology
MH  - Antigens, CD/genetics/metabolism
MH  - Family Characteristics
MH  - Female
MH  - Genotype
MH  - HLA Antigens/genetics/metabolism
MH  - Histocompatibility Antigens Class I/genetics/metabolism
MH  - Humans
MH  - Killer Cells, Natural/cytology/immunology/*metabolism
MH  - Lectins, C-Type/genetics/metabolism
MH  - Male
MH  - NK Cell Lectin-Like Receptor Subfamily C
MH  - NK Cell Lectin-Like Receptor Subfamily D
MH  - Polymerase Chain Reaction/methods
MH  - Pregnancy
MH  - Receptors, Immunologic/*genetics/metabolism
MH  - Receptors, KIR
MH  - Receptors, KIR2DL1
MH  - Receptors, Natural Killer Cell
MH  - Trophoblasts/immunology/metabolism
EDAT- 2003/06/12 05:00
MHDA- 2003/10/11 05:00
CRDT- 2003/06/12 05:00
PHST- 2003/06/12 05:00 [pubmed]
PHST- 2003/10/11 05:00 [medline]
PHST- 2003/06/12 05:00 [entrez]
AID - 10.1034/j.1600-0897.2003.00018.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2003 Mar;49(3):183-91. doi: 
      10.1034/j.1600-0897.2003.00018.x.