PMID- 12798405
OWN - NLM
STAT- MEDLINE
DCOM- 20030929
LR  - 20191107
IS  - 1368-8375 (Print)
IS  - 1368-8375 (Linking)
VI  - 39
IP  - 6
DP  - 2003 Sep
TI  - Prognostic significance of cyclin D1 amplification and overexpression in oral 
      squamous cell carcinomas.
PG  - 610-8
AB  - Amplification and overexpression of cyclin D1 (CCND1) have been reported as 
      independent prognostic indicators of several tumors. To investigate the 
      association between CCND1 amplification and overexpression in oral squamous cell 
      carcinomas (OSCCs), and to determine which is more reliable as a prognostic 
      indicator, fluorescence in situ hybridization (FISH) on fine-needle aspiration 
      (FNA) biopsies and immunohistochemistry were performed on 41 primary OSCCs (26 
      males, 15 females; mean age; 58.4 years, range 21-89 years). Thirteen patients 
      were stage I, 13 were stage II, nine were stage III, and six were stage IV. CCND1 
      amplification and overexpression was detected in 13 (31.7%) and 27 (65.9%) of 41 
      cases. CCND1 was overexpressed in all cases showing CCND1 amplification. On the 
      other hand, CCND1 overexpression was also detected in 14 of 28 cases (50.0%) 
      lacked such amplification. Statistical analysis showed that the correlation 
      between CCND1 overexpression and decreased survival just failed to reach 
      statistical significance, and CCND1 amplification and nodal status were 
      independent prognostic indicators. In conclusion, it will be necessary to 
      investigate the other pathways that regulate CCND1 expression besides CCND1 
      amplification. From the present study, CCND1 amplification is a more reliable 
      prognostic indicator than CCND1 overexpression in OSCCs.
FAU - Miyamoto, Ryozo
AU  - Miyamoto R
AD  - Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of 
      Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental 
      University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. 
      ryou-m.mfs@tmd.ac.jp
FAU - Uzawa, Narikazu
AU  - Uzawa N
FAU - Nagaoka, Shunya
AU  - Nagaoka S
FAU - Hirata, Yasushi
AU  - Hirata Y
FAU - Amagasa, Teruo
AU  - Amagasa T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
RN  - 0 (Genetic Markers)
RN  - 0 (RNA, Messenger)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy, Needle
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/mortality
MH  - Cyclin D1/*genetics
MH  - Disease-Free Survival
MH  - Female
MH  - Gene Amplification
MH  - Gene Expression
MH  - Genetic Markers
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*genetics/metabolism/mortality
MH  - Prognosis
MH  - RNA, Messenger/*analysis
MH  - Survival Rate
EDAT- 2003/06/12 05:00
MHDA- 2003/09/30 05:00
CRDT- 2003/06/12 05:00
PHST- 2003/06/12 05:00 [pubmed]
PHST- 2003/09/30 05:00 [medline]
PHST- 2003/06/12 05:00 [entrez]
AID - S1368837503000484 [pii]
AID - 10.1016/s1368-8375(03)00048-4 [doi]
PST - ppublish
SO  - Oral Oncol. 2003 Sep;39(6):610-8. doi: 10.1016/s1368-8375(03)00048-4.