PMID- 12798452
OWN - NLM
STAT- MEDLINE
DCOM- 20030709
LR  - 20220318
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 114
IP  - 8
DP  - 2003 Jun 1
TI  - HLA-DRB1 status affects endothelial function in treated patients with rheumatoid 
      arthritis.
PG  - 647-52
AB  - PURPOSE: To examine endothelial function in rheumatoid arthritis patients and to 
      assess whether clinical or genetic factors affect the development of endothelial 
      dysfunction. METHODS: Fifty-five patients fulfilling the 1987 American College of 
      Rheumatology classification criteria for rheumatoid arthritis were recruited from 
      Hospital Xeral-Calde, Lugo, Spain. Patients were required to have been treated 
      for at least 5 years, including current treatment with one or more 
      disease-modifying antirheumatic drugs. Patients with diabetes mellitus, renal 
      insufficiency, or cardiovascular disease were excluded. Thirty-one age-, sex-, 
      and ethnically matched controls were also studied. Endothelium-dependent 
      (postischemia) and -independent (postnitroglycerin) vasodilatation were measured 
      by brachial ultrasonography. Patients were genotyped for human leukocyte antigen 
      (HLA)-DRB1. RESULTS: Patients had decreased endothelium-dependent vasodilatation 
      (mean [+/- SD], 3.8% +/- 4.9%) compared with controls (8.0% +/- 4.5%; P <0.001). 
      There were no differences in endothelium-independent vasodilatation. Clinical 
      features were not associated with endothelial dysfunction. Endothelium-dependent 
      vasodilatation was lower in the 30 rheumatoid arthritis patients with the 
      HLA-DRB1*04 shared epitope alleles (2.4% +/- 4.1%) than in the remaining patients 
      (5.5% +/- 5.3%; P = 0.01). Similar results were seen for patients with the 
      HLA-DRB1*0404 shared epitope allele (-0.4% +/- 2.5%) compared with other patients 
      (4.4% +/- 4.9%; P = 0.01). CONCLUSION: Patients with chronically treated 
      rheumatoid arthritis had evidence of endothelial dysfunction, especially those 
      with certain HLA-DRB1 genotypes. If confirmed, our results suggest that HLA-DRB1 
      status may be a predictor of cardiovascular risk in these patients.
FAU - Gonzalez-Juanatey, Carlos
AU  - Gonzalez-Juanatey C
AD  - Division of Cardiology, Hospital Xeral-Calde, Dr. Ochoa s/n, 27004 Lugo, Spain.
FAU - Testa, Ana
AU  - Testa A
FAU - Garcia-Castelo, Alberto
AU  - Garcia-Castelo A
FAU - Garcia-Porrua, Carlos
AU  - Garcia-Porrua C
FAU - Llorca, Javier
AU  - Llorca J
FAU - Vidan, Juan
AU  - Vidan J
FAU - Hajeer, Ali H
AU  - Hajeer AH
FAU - Ollier, William E
AU  - Ollier WE
FAU - Mattey, Derek L
AU  - Mattey DL
FAU - Gonzalez-Gay, Miguel A
AU  - Gonzalez-Gay MA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/genetics/*physiopathology
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - *HLA-DR Antigens
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Vasodilation
EDAT- 2003/06/12 05:00
MHDA- 2003/07/10 05:00
CRDT- 2003/06/12 05:00
PHST- 2003/06/12 05:00 [pubmed]
PHST- 2003/07/10 05:00 [medline]
PHST- 2003/06/12 05:00 [entrez]
AID - S0002934303001335 [pii]
AID - 10.1016/s0002-9343(03)00133-5 [doi]
PST - ppublish
SO  - Am J Med. 2003 Jun 1;114(8):647-52. doi: 10.1016/s0002-9343(03)00133-5.