PMID- 12800411
OWN - NLM
STAT- MEDLINE
DCOM- 20030904
LR  - 20161124
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 23
IP  - 5
DP  - 2003 May
TI  - [A comparative study of manchurian Dutchmanspipe and antibiotics induced acute 
      tubular necrosis in renal cellular biological features].
PG  - 329-34
AB  - OBJECTIVE: To explore the possible cell biological mechanisms of the difference 
      in prognosis between the acute tubular necrosis (ATN) induced by Manchurian 
      Dutchmanspipe (MD-ATN) and that by antibiotics (A-ATN), by means of comparing 
      their renal tubular mesenchymal cell phenotype characteristics and extra-cellular 
      stroma secretion. METHODS: The expression of proliferative cell nuclear antigen 
      (PCNA), epithelial cell growth factor (EGF), alpha-smooth muscle actin 
      (alpha-SMA), fibronectin (FN), collagen type III and IV, transforming growth 
      factor beta 1 (TGF beta 1) and connective tissue growth factor in renal biopsy 
      samples of patients with MD-ATN (4 patients) and A-ATN(5 patients) were compared 
      with immunohistochemical SP method. The analysis of above-mentioned parameters on 
      repairing of injury and development of fibrosis was stressed for the obvious 
      difference in clinical prognosis between the two groups. RESULTS: (1) The PCNA 
      positive rate of renal tubular epithelial cell (RTEC) and EGF expression in the 
      MD-ATN group were significantly lower than those in the A-ATN group respectively 
      (P < 0.01); (2) Renal tubular mesenchymal alpha-SMA level increased in both 
      groups with no significant difference; (3) TGF beta 1 positive cell infiltration 
      and obvious CTGF expression revealed in renal mesenchyma of both groups with 
      insignificant difference; (4) FN, collagen III and IV levels were significantly 
      higher in the MD-ATN group than that in the A-ATN group (P < 0.05). CONCLUSION: 
      (1) As compared with A-ATN group, the RTEC auto-repairing ability was lower in 
      the DM-ATN group, lower expression of EGF might be one of the mechanisms of its 
      poor repair; (2) High expression of alpha-SMA, TGF beta 1 and CTGF presented in 
      all patients with ATN, but extra-cellular stromal deposit appeared only in the 
      renal stroma of patients with MD-ATN, suggesting that its chronical trend might 
      be related with the reducing of extra-cellular stromal degradation factor and/or 
      endogenous anti-fibrosis factor.
FAU - Yang, Li
AU  - Yang L
AD  - Renal Division of Department of Medicine, First Hospital and Institute of 
      Nephrology, Peking University, Beijing 100034.
FAU - Li, Xiao-mei
AU  - Li XM
FAU - Wang, Hai-yan
AU  - Wang HY
LA  - chi
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Aminoglycosides)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Aristolochic Acids)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Fibronectins)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - 94218WFP5T (aristolochic acid I)
SB  - IM
MH  - Adult
MH  - Aminoglycosides
MH  - Anti-Bacterial Agents/*adverse effects
MH  - Aristolochia/chemistry
MH  - Aristolochic Acids/*adverse effects
MH  - Biopsy, Needle
MH  - Drugs, Chinese Herbal/*adverse effects
MH  - Female
MH  - Fibronectins/biosynthesis
MH  - Fibrosis
MH  - Humans
MH  - Kidney/pathology
MH  - Kidney Tubular Necrosis, Acute/*chemically induced/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proliferating Cell Nuclear Antigen/biosynthesis
EDAT- 2003/06/13 05:00
MHDA- 2003/09/05 05:00
CRDT- 2003/06/13 05:00
PHST- 2003/06/13 05:00 [pubmed]
PHST- 2003/09/05 05:00 [medline]
PHST- 2003/06/13 05:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 May;23(5):329-34.