PMID- 12801800
OWN - NLM
STAT- MEDLINE
DCOM- 20030902
LR  - 20220309
IS  - 0369-8114 (Print)
IS  - 0369-8114 (Linking)
VI  - 51
IP  - 2
DP  - 2003 Mar
TI  - The control of immunity and tolerance by dendritic cell.
PG  - 59-60
AB  - Dendritic cells (DCs) are best known for their roles in host resistance and 
      immunogenicity. DCs provide a direct link between innate and adaptive immunity. 
      After antigen capture and processing, DCs control the differentiation and 
      polarization of T cells. However, there is a danger during the antigen 
      presentation because, at the same time DCs are capturing microbial antigens and 
      also dying self cells and environmental proteins, to which the immune system must 
      not respond. There is good evidence that immature DCs, in the absence of 
      infection and inflammation, induce immunological tolerance to innocuous self 
      antigens, avoiding then a non-appropriate response to harmless antigens that may 
      be presented subsequently when infection strikes.
FAU - Steinman, R M
AU  - Steinman RM
AD  - Laboratory of Cellular Physiology & Immunology, The Rockefeller University, New 
      York, NY 10021-6399, USA. steinma@rockvax.rockfeller.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Pathol Biol (Paris)
JT  - Pathologie-biologie
JID - 0265365
RN  - 0 (Autoantigens)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Autoantigens/immunology
MH  - Cell Differentiation
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance/*immunology
MH  - Infections/immunology
MH  - Self Tolerance/immunology
MH  - T-Lymphocyte Subsets/cytology/immunology
RF  - 0
EDAT- 2003/06/13 05:00
MHDA- 2003/09/03 05:00
CRDT- 2003/06/13 05:00
PHST- 2003/06/13 05:00 [pubmed]
PHST- 2003/09/03 05:00 [medline]
PHST- 2003/06/13 05:00 [entrez]
AID - S0369811403000968 [pii]
AID - 10.1016/s0369-8114(03)00096-8 [doi]
PST - ppublish
SO  - Pathol Biol (Paris). 2003 Mar;51(2):59-60. doi: 10.1016/s0369-8114(03)00096-8.