PMID- 1280228
OWN - NLM
STAT- MEDLINE
DCOM- 19921224
LR  - 20221207
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 228
IP  - 2-3
DP  - 1992 Sep 1
TI  - Antagonism of 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat 
      brain by 1-piperonylpiperazine.
PG  - 171-4
AB  - The effects of 1-piperonylpiperazine and N,alpha-dimethylpiperonylamine, which 
      are weak inhibitors for [3H]5-hydroxytryptamine (5-HT) uptake, on 
      3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity were examined. The 
      reductions of serotonergic parameters in the rat cerebral cortex produced by 
      multiple administration of MDMA (10 mg/kg) were attenuated significantly by 
      coadministration of 6-nitroquipazine (10 mg/kg), paroxetine (10 mg/kg) or 
      1-piperonylpiperazine (20 mg/kg), but not by N,alpha-dimethylpiperonylamine (20 
      mg/kg). The present data suggest that 1-piperonylpiperazine might inhibit the 
      MDMA-induced neurotoxicity by effect(s) other than 5-HT uptake inhibition.
FAU - Hashimoto, K
AU  - Hashimoto K
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, 
      Japan.
FAU - Maeda, H
AU  - Maeda H
FAU - Goromaru, T
AU  - Goromaru T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Piperazines)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 32231-06-4 (1-piperonylpiperazine)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 4WCY05C0SJ (Quipazine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - 77372-73-7 (6-nitroquipazine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/antagonists & 
      inhibitors/toxicity
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Injections, Intraperitoneal
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Piperazines/*pharmacology
MH  - Quipazine/analogs & derivatives/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/metabolism
MH  - Serotonin Antagonists/pharmacology
MH  - Selective Serotonin Reuptake Inhibitors/*pharmacology
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1016/0926-6917(92)90027-a [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1992 Sep 1;228(2-3):171-4. doi: 10.1016/0926-6917(92)90027-a.