PMID- 12802818
OWN - NLM
STAT- MEDLINE
DCOM- 20031120
LR  - 20061115
IS  - 0277-6715 (Print)
IS  - 0277-6715 (Linking)
VI  - 22
IP  - 12
DP  - 2003 Jun 30
TI  - Comparing HLA antigen frequencies between two groups of patients.
PG  - 1999-2013
AB  - For diseases that involve the immune system, the alleles of the human leukocyte 
      antigen (HLA) complex can play a major role. For example, if responsiveness to 
      therapy is immunologically mediated, one would think that responders and 
      non-responders might tend to have different HLA alleles. However, comparing the 
      frequencies between the two groups of patients at each allele can introduce a 
      substantial multiple comparisons problem as the number of alleles is large. This 
      paper proposes an efficient two-stage procedure for identifying alleles that may 
      mediate response. In the first-stage, the distribution of all alleles for the 
      patients are compared to a reference population and a few alleles are selected. 
      These candidate alleles are then compared between the two groups of patients 
      using a modest Bonferroni correction. The two-stage procedure strongly controls 
      the type I error rate as the first-stage selection is statistically independent 
      of the second-stage tests. We analyse a cohort of patients with bone marrow 
      failure who are classified as responders or non-responders to immunosuppressive 
      therapy. Published in 2003 by John Wiley & Sons, Ltd.
FAU - Follmann, Dean A
AU  - Follmann DA
AD  - Office of Biostatistics Research, National Heart, Lung and Blood Institute, 
      NIH/DHHS, 2 Rockledge Center, Bethesda, MD 20892-7938, U.S.A. 
      follmannd@nhlbi.nih.gov
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Alleles
MH  - Antigenic Variation/immunology
MH  - Bone Marrow Transplantation/immunology
MH  - Cohort Studies
MH  - Graft Rejection/immunology
MH  - HLA Antigens/*genetics/*immunology
MH  - Humans
MH  - *Models, Biological
MH  - Models, Statistical
EDAT- 2003/06/13 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/06/13 05:00
PHST- 2003/06/13 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/06/13 05:00 [entrez]
AID - 10.1002/sim.1426 [doi]
PST - ppublish
SO  - Stat Med. 2003 Jun 30;22(12):1999-2013. doi: 10.1002/sim.1426.