PMID- 12803487
OWN - NLM
STAT- MEDLINE
DCOM- 20030717
LR  - 20240315
IS  - 1016-8478 (Print)
IS  - 1016-8478 (Linking)
VI  - 15
IP  - 2
DP  - 2003 Apr 30
TI  - The effect of brain-derived neurotrophic factor on neuritogenesis and synaptic 
      plasticity in Aplysia neurons and the hippocampal cell line HiB5.
PG  - 233-9
AB  - Brain-derived neurotrophic factor (BDNF) plays a key role in the differentiation 
      and neuritogenesis of developing neurons, and in the synaptic plasticity of 
      mature neurons, in the mammalian nervous system. BDNF binds to the receptor 
      tyrosine kinase TrkB and transmits neurotrophic signals by activating 
      neuron-specific tyrosine phosphorylation pathways. However, the neurotrophic 
      function of BDNF in Aplysia neurons is poorly understood. We examined the 
      specific effect of BDNF on neurite outgrowth and synaptic plasticity in cultured 
      Aplysia neurons and a multipotent rat hippocampal stem cell line (HiB5). Our 
      study indicates that mammalian BDNF has no significant effect on the 
      neuritogenesis, neurotransmitter release, excitability, and synaptic plasticity 
      of cultured Aplysia neurons in our experimental conditions. In contrast, BDNF in 
      combination with platelet-derived growth factor (PDGF) increases the length of 
      the neurites and the number of spine-like structures in cells of HiB5.
FAU - Lee, Seung-Hee
AU  - Lee SH
AD  - National Research Laboratory of Neurobiology, Institute of Molecular Biology and 
      Genetics, School of Biological Sciences, Seoul National University, Seoul 
      151-742, Korea.
FAU - Han, Jin-Hee
AU  - Han JH
FAU - Choi, Jung-Hwan
AU  - Choi JH
FAU - Huh, Eun-Young
AU  - Huh EY
FAU - Kwon, Yunhee Kim
AU  - Kwon YK
FAU - Kaang, Bong-Kiun
AU  - Kaang BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Aplysia/drug effects/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cell Line
MH  - Hippocampus/drug effects/embryology/*metabolism
MH  - Mammals/genetics/metabolism
MH  - Neurons/drug effects/metabolism
MH  - Synapses/*drug effects
EDAT- 2003/06/14 05:00
MHDA- 2003/07/19 05:00
CRDT- 2003/06/14 05:00
PHST- 2003/06/14 05:00 [pubmed]
PHST- 2003/07/19 05:00 [medline]
PHST- 2003/06/14 05:00 [entrez]
AID - S1016-8478(23)13732-0 [pii]
PST - ppublish
SO  - Mol Cells. 2003 Apr 30;15(2):233-9.