PMID- 12804790
OWN - NLM
STAT- MEDLINE
DCOM- 20030814
LR  - 20190916
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 46
IP  - 3
DP  - 2003 Jul
TI  - Neurodegeneration of substantia nigra accompanied with macrophage/microglia 
      infiltration after intrastriatal hemorrhage.
PG  - 289-98
AB  - Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra 
      (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) 
      cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 
      mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the 
      expression of both brain-derived neurotrophic factor (BDNF) mRNA and BDNF, 
      suggesting that activated-p38 MAPK(+)/ED1(+) cells would produce BDNF and may 
      exhibit trophic effect on the degenerating neurons in the SN. However, in ELISA, 
      BDNF protein decreased significantly in ipsilateral SN at 7 days after 
      hemorrhage, which may be due to a dramatic decrease of BDNF immunoreactive 
      neurons in pars compacta. Data suggest that activation of p38 MAPK in ED1(+) 
      cells infiltrating in ipsilateral SN after hemorrhage may produce BDNF, but that 
      the amount of BDNF produced from ED1(+) cells is insufficient for the rescue of 
      degenerating neurons.
FAU - Imamura, Nobuki
AU  - Imamura N
AD  - Department of Neurosurgery and Restorative Neuroscience, Nagoya City University 
      Graduate School of Medical Sciences, Kawasumi 1, Mizoho-cho, Mizuho-ku, 467-8601, 
      Nagoya, Japan.
FAU - Hida, Hideki
AU  - Hida H
FAU - Aihara, Noritaka
AU  - Aihara N
FAU - Ishida, Kazuto
AU  - Ishida K
FAU - Kanda, Yoshie
AU  - Kanda Y
FAU - Nishino, Hitoo
AU  - Nishino H
FAU - Yamada, Kazuo
AU  - Yamada K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Ectodysplasins)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - 44RAL3456C (Methamphetamine)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 3.4.24.- (Collagenases)
RN  - N21FAR7B4S (Apomorphine)
SB  - IM
MH  - Animals
MH  - Apomorphine/pharmacology
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/genetics
MH  - Central Nervous System Stimulants/pharmacology
MH  - Cerebral Hemorrhage/chemically induced/*complications/metabolism/pathology
MH  - Collagenases/toxicity
MH  - Disease Models, Animal
MH  - Dopamine Agonists/pharmacology
MH  - Ectodysplasins
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Functional Laterality
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Macrophages/*metabolism/pathology
MH  - Male
MH  - Membrane Proteins/metabolism
MH  - Methamphetamine/pharmacology
MH  - Microglia/*metabolism/pathology
MH  - Mitogen-Activated Protein Kinases/biosynthesis
MH  - Nerve Degeneration/*etiology/metabolism/pathology
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Wistar
MH  - Rotation
MH  - Substantia Nigra/metabolism/*pathology
MH  - Time Factors
MH  - Tyrosine 3-Monooxygenase/metabolism
MH  - p38 Mitogen-Activated Protein Kinases
EDAT- 2003/06/14 05:00
MHDA- 2003/08/15 05:00
CRDT- 2003/06/14 05:00
PHST- 2003/06/14 05:00 [pubmed]
PHST- 2003/08/15 05:00 [medline]
PHST- 2003/06/14 05:00 [entrez]
AID - S0168010203000658 [pii]
AID - 10.1016/s0168-0102(03)00065-8 [doi]
PST - ppublish
SO  - Neurosci Res. 2003 Jul;46(3):289-98. doi: 10.1016/s0168-0102(03)00065-8.