PMID- 12804984
OWN - NLM
STAT- MEDLINE
DCOM- 20030930
LR  - 20161124
IS  - 1167-1122 (Print)
IS  - 1167-1122 (Linking)
VI  - 13
IP  - 3
DP  - 2003 May-Jun
TI  - Lack of upregulation of epidermal fatty acid binding protein in dithranol induced 
      irritation.
PG  - 254-7
AB  - The exact role of epidermal fatty acid binding protein (E-FABP) in skin is 
      unknown. A restoration of the barrier function may be associated with an 
      upregulation of E-FABP. Moreover, E-FABP is upregulated in a variety of cells in 
      response to oxidative stress. A recent observation that dithranol induced 
      irritation is not associated with skin barrier impairment prompted us to 
      investigate the expression of E-FABP in this skin condition to elucidate the 
      unknown function of this protein in skin. This study shows lack of E-FABP 
      upregulation after a single application of dithranol on uninvolved skin of 
      patients with psoriasis. The expression of E-FABP in dithranol irritation 
      correlates with the unimpaired skin barrier function as assessed by measurements 
      of TEWL. Furthermore, we did not find evidence for the recently introduced 
      hypothesis that E-FABP functions as an antioxidant protein in the skin irritation 
      induced by dithranol as oxidative stressor.
FAU - Kucharekova, Martin
AU  - Kucharekova M
AD  - Department of Dermatology, University Medical Centre Nijmegen, P.O. Box 9101, 
      6500 HB Nijmegen, The Netherlands. mkucharekova@derma.umcn.nl
FAU - Vissers, Wynand H P M
AU  - Vissers WH
FAU - Schalkwijk, Joost J
AU  - Schalkwijk JJ
FAU - van de Kerkhof, Peter C M
AU  - van de Kerkhof PC
FAU - van der Valk, Peter G M
AU  - van der Valk PG
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
RN  - 0 (Carrier Proteins)
RN  - 0 (FABP5 protein, human)
RN  - 0 (FABP7 protein, human)
RN  - 0 (Fatty Acid-Binding Protein 7)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Tumor Suppressor Proteins)
RN  - U8CJK0JH5M (Anthralin)
SB  - IM
MH  - Administration, Topical
MH  - Aged
MH  - *Anthralin/administration & dosage
MH  - Carrier Proteins/*metabolism
MH  - Erythema/chemically induced/*metabolism
MH  - Fatty Acid-Binding Protein 7
MH  - Fatty Acid-Binding Proteins
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Proteins
MH  - *Tumor Suppressor Proteins
MH  - Up-Regulation
MH  - Water Loss, Insensible
EDAT- 2003/06/14 05:00
MHDA- 2003/10/01 05:00
CRDT- 2003/06/14 05:00
PHST- 2003/06/14 05:00 [pubmed]
PHST- 2003/10/01 05:00 [medline]
PHST- 2003/06/14 05:00 [entrez]
PST - ppublish
SO  - Eur J Dermatol. 2003 May-Jun;13(3):254-7.