PMID- 12808324
OWN - NLM
STAT- MEDLINE
DCOM- 20040223
LR  - 20110316
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 18
IP  - 3
DP  - 2003 Jun
TI  - Active immunization using dendritic cells mixed with tumor cells inhibits the 
      growth of lymphomas.
PG  - 372-80
AB  - Dendritic cells (DCs) are potent antigen-presenting cells for the induction and 
      activation of cytotoxic T lymphocytes. We tested whether bone marrow-derived DCs 
      are capable of inducing protective immunity against a murine lymphoma (A20). DCs 
      were grown from tumor-bearing BALB/c mice by culturing bone marrow cells. BALB/c 
      mice were injected (sc) with A20 cells on day 0. Intraperitoneal immunization 
      with DCs mixed with lethally irradiated A20 cells were started when the tumor 
      reached ca. 4-5 mm in diameter (Group A) or on day -7 (Group B). Booster 
      immunizations were given every 3-4 days for four weeks. By 31 days in group A, 
      there was a significant reduction in tumor growth in the mice immunized with DCs 
      mixed with irradiated A20 cells as compared with the control groups (p=0.016). In 
      group B, tumor growth was completely inhibited and there was no tumor growth 
      following extended observations after completion of immunization. Thus, DCs mixed 
      with irradiated tumor cells can induce an antitumor effect. This provides a 
      rationale for the use of DCs mixed with irradiated tumor cells in immunotherapy 
      for minimal residual disease of lymphomas.
FAU - Park, Jin Ny
AU  - Park JN
AD  - Department of Medicine, College of Medicine, University of Ulsan, Seoul, Korea.
FAU - Suh, Cheolwon
AU  - Suh C
FAU - Yang, Jehoon
AU  - Yang J
FAU - Park, Jung Sun
AU  - Park JS
FAU - Park, Keon Uk
AU  - Park KU
FAU - Min, Young Joo
AU  - Min YJ
FAU - Kim, Hyo Jung
AU  - Kim HJ
FAU - Kim, Young-Hoon
AU  - Kim YH
FAU - Kim, Sang-Hee
AU  - Kim SH
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - Animals
MH  - Apoptosis/immunology
MH  - Bone Marrow Cells/immunology
MH  - Cell Division/immunology
MH  - Cell Line, Tumor
MH  - Dendritic Cells/*immunology/transplantation
MH  - Female
MH  - Immunization/*methods
MH  - Lymphocyte Culture Test, Mixed
MH  - Lymphoma/*immunology/pathology/*therapy
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neoplasm Transplantation
MH  - T-Lymphocytes, Cytotoxic/immunology
PMC - PMC3055039
EDAT- 2003/06/17 05:00
MHDA- 2004/02/24 05:00
PMCR- 2003/06/01
CRDT- 2003/06/17 05:00
PHST- 2003/06/17 05:00 [pubmed]
PHST- 2004/02/24 05:00 [medline]
PHST- 2003/06/17 05:00 [entrez]
PHST- 2003/06/01 00:00 [pmc-release]
AID - 200306372 [pii]
AID - 10.3346/jkms.2003.18.3.372 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2003 Jun;18(3):372-80. doi: 10.3346/jkms.2003.18.3.372.