PMID- 1280863
OWN - NLM
STAT- MEDLINE
DCOM- 19930107
LR  - 20141120
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 68
IP  - 5
DP  - 1992 Nov 10
TI  - Influence of selected heparins on human neutrophil functions in vitro.
PG  - 556-62
AB  - The effects of four heparin derivatives [unfractionated heparin (UFH) at 5-50 
      IU/ml, low molecular weight heparin (LMWH) at 2-20 IU/ml, pentasaccharide (Penta) 
      at 5 IU/ml and a synthetic heparinoid (PPS) at 10(-6)-10(-5) M] on various 
      polymorphonuclear (PMN) leukocyte end-functions (aggregation, chemotaxis, 
      phagocytosis and burst) were examined. CR3 expression, actin polymerization and 
      membrane surface charge were also studied to gain more insight on the mechanisms 
      of the action of heparins on PMN. The different heparins were found to have 
      rather different actions. PMN were found to be hyperreactive to PPS. 
      Pentasaccharide hat no effect on PMN functions, while UFH and LMWH had 
      intermediate reactivity, modulating responses in an adenosine-like manner. 
      Interactions of heparins with PMN were attributed to biophysical properties of 
      the molecules rather than to the presence of a specific sequence such as a 
      pentasaccharide. Our results show that certain heparin derivatives, apart their 
      well-known anticoagulant action, modulate polymorphonuclear leukocyte functions 
      that may be involved in vascular injury.
FAU - Labrouche, S
AU  - Labrouche S
AD  - INSERM Unite 8, Pessac-Bordeaux, France.
FAU - Freyburger, G
AU  - Freyburger G
FAU - Belloc, F
AU  - Belloc F
FAU - Boisseau, M R
AU  - Boisseau MR
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Actins)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Macrophage-1 Antigen)
RN  - 37300-21-3 (Pentosan Sulfuric Polyester)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Actins/metabolism
MH  - Cell Aggregation/drug effects
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Cytoskeleton/metabolism
MH  - Heparin/*pharmacology
MH  - Heparin, Low-Molecular-Weight/pharmacology
MH  - Humans
MH  - In Vitro Techniques
MH  - Macrophage-1 Antigen/metabolism
MH  - Membrane Potentials/drug effects
MH  - Neutrophils/*drug effects/immunology/physiology
MH  - Pentosan Sulfuric Polyester/pharmacology
MH  - Phagocytosis/drug effects
MH  - Respiratory Burst/drug effects
EDAT- 1992/11/10 00:00
MHDA- 1992/11/10 00:01
CRDT- 1992/11/10 00:00
PHST- 1992/11/10 00:00 [pubmed]
PHST- 1992/11/10 00:01 [medline]
PHST- 1992/11/10 00:00 [entrez]
PST - ppublish
SO  - Thromb Haemost. 1992 Nov 10;68(5):556-62.